IndraLab

Statements

USP25 leads to the deubiquitination of TNKS. 3 / 4
1 | 3
reach
"As shown in Fig. 4 E, while USP25 inhibited the ubiquitination of TNKS mediated by RNF146, adding of C44 restored the ubiquitination of TNKS."
30472184
reach
"TNKS1 ubiquitination level was knowingly increased in USP25-knockdown glioma cells and reduced in USP25-overexpressed glioma cells, suggesting TNKS1 ubiquitination levels were negatively regulated by USP25."
35450028
reach
"These results indicate that UAT-B could disrupting USP25-mediated stabilization and deubiquitination of TNKS, thereby encouraging Axin 1 to drive the degradation of β-catenin.3.4 UAT-B inhibits TNKS-dependent Wnt pathway to overcome multi-drug resistance."
38261825