IndraLab
Statements
"PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11"
reach
"These mechanisms might be of therapeutic importance in cancer, because defective HR renders cells susceptible to inhibition of base excision repair (BER) mediated by poly (ADP-ribose) polymerase 1 (PARP1) XREF_BIBR - XREF_BIBR : the deubiquitylating enzyme (DUB) ubiquitin carboxyl-terminal hydrolase 11 (USP11) deubiquitylates partner and localizer of BRCA2 (PALB2) during S and G2 phases following DNA damage, allowing the formation of the BRCA1, PALB2, and BRCA2 complex and HR repair to advance in these phases of the cell cycle 64."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."
USP11 affects Nucleoproteins
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4
USP11 deubiquitinates Nucleoproteins. 3 / 3
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3
USP11 deubiquitinates Nucleoproteins on K187. 1 / 1
|
1
reach
"25
,
26
,
27
Recently, USP11 was shown to promote HCC development,
28
but the underlying molecular mechanisms involved in this pathogenic process remain poorly understood.In this study, we used a proteomic approach to identify KLF4‐interacting DUBs and firstly discovered that USP11 was responsible for deubiquitinating KLF4 in HCC cells."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
USP11 affects TGFbeta receptor
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2
USP11 affects SUMO-ubiquitin chains
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2
USP11 affects Histone_H2B
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2
USP11 deubiquitinates Histone_H2B on K120. 1 / 1
|
1
USP11 leads to the deubiquitination of Histone_H2B. 1 / 1
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1
USP11 affects hybrid SUMO2-ubiquitin chains
|
1
reach
"USP-11 deubiquitylates specific substrates which play key roles in correct microtubule nucleation (RanBPM) [XREF_BIBR]; antigen presenting cell function (RELB) [XREF_BIBR]; inflammation, immunity, cell proliferation and apoptosis (TNFa induced NK-kB, and IKKa and p53 signaling pathway) [XREF_BIBR, XREF_BIBR]; and E7 modulated cell growth and transformation (HPV-16E7) [XREF_BIBR]."