IndraLab

Statements


USP11 affects TGFBR1
1 | 9
USP11 deubiquitinates TGFBR1. 10 / 10
1 | 9

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"USP11 deubiquitylates ALK5."

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"It has been revealed that the DUBs, UCH37, USP11, and USP15, de-ubiquitinate and stabilize TbetaRI."

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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR In this study, we show that USP11 has no effect on TbetaRI stability in human lung fibroblast cells, though Al-Salihi et al. 21 showed that USP11 de-ubiquitinates TbetaRI."

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"USP11 augments TGFbeta signalling by deubiquitylating ALK5."

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"USP11 was able to reduce ALK5 polyubiquitylation, although not to basal levels."

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."

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"For example, the closely related DUBs USP4, USP11 and USP15 have been reported to modulate TGFbeta signalling by deubiquitylating the type I TGFbeta receptor ALK5 [XREF_BIBR - XREF_BIBR]."

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"Over-expressed wt USP11 was able to deubiquitylate ALK5."

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"Likely, USP11 is also involved in the TGF/BMP signaling pathway by deubiquitylating ALK5 [98]."
USP11 affects SPRTN
| 10
USP11 deubiquitinates SPRTN. 8 / 8
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"Neither VCPIP1 nor USP11 induce SPRTN deubiquitylation when overexpressed, while USP7 does (XREF_SUPPLEMENTARY)."

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"USP11 deubiquitinates SPRTN in cells and invitro."

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"However, we observe that lack of SPRTN deubiquitination by USP11 and VCPIP1 did not affect recruitment on chromatin."

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"USP11 deubiquitinates SPRTN upon DPC induction."

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"To show that deubiquitination of SPRTN by USP11 is direct, we purified SFB-SPRTN, Myc-USP11, and Myc-USP11 C318S proteins from HEK 293T cells and performed an invitro DUB reaction by incubating SFB-SPRTN alone or with Myc-USP11 or Myc-USP11 C318S purified proteins."

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"We observed that USP11, but not USP11 C318S catalytic mutant, deubiquitinated SPRTN (XREF_FIG E, anti-Ub blot) and reduced SPRTN auto-cleavage products (XREF_FIG E, IP blot)."

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"Upon formaldehyde treatment and other yet to be identified signals, SPRTN is deubiquitinated by USP11 (this study), USP7, and VCPIP1."

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"USP11 mediates repair of DNA protein cross-links by deubiquitinating SPRTN metalloprotease."
USP11 deubiquitinates ubiquitinated SPRTN. 1 / 1
| 1

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"We observed that monoubiquitinated SPRTN is deubiquitinated by USP11 FL, but not C318S deubiquitinase inactive mutant (XREF_FIG C and Fig.S2A)."
USP11-C318S deubiquitinates SPRTN. 1 / 1
| 1

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"We observed that USP11, but not USP11 C318S catalytic mutant, deubiquitinated SPRTN (XREF_FIG E, anti-Ub blot) and reduced SPRTN auto-cleavage products (XREF_FIG E, IP blot)."
USP11 affects PML
1 | 1 8
USP11 deubiquitinates PML. 8 / 8
1 | 1 6

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"USP11 deubiquitinates and stabilizes PML, thereby counteracting the functions of PML ubiquitin ligases RNF4 and the KLHL20-Cul3 (Cullin 3) and Roc1 complex."

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"Remarkably, USP11 was able to antagonize RNF4- and Roc1-Cul3-KLHL20-mediated PML ubiquitination in 293T cells and GBM cell line U87 (XREF_SUPPLEMENTARY)."

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"Next, we determined whether USP11 could deubiquitinate PML in vitro."

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"USP11 deubiquitinates and stabilizes PML, thereby counteracting the functions of PML ubiquitin ligases RNF4 and the KLHL20-Cul3 (Cullin 3)-Roc1 complex."

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"By contrast, USP11 promotes deubiquitination and stabilization of PML [XREF_BIBR]."

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"USP11 deubiquitinates PML."

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"We demonstrated that USP11 deubiquitinates and stabilizes PML."
Modified USP11 leads to the deubiquitination of PML. 2 / 2
| 2

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"Importantly, the NIC induced PML ubiquitination was abrogated by Hey1 depletion or USP11 overexpression (XREF_FIG)."

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"In the reciprocal experiment, overexpression of USP11, but not its catalytically inactive mutant, reduced PML ubiquitination (XREF_FIG)."
USP11 affects TGFBR2
1 | 8
USP11 deubiquitinates TGFBR2. 7 / 7
1 | 6

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"The novel finding in this study is that USP11 de-ubiquitinates and stabilizes TbetaRII."

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"USP11 de-ubiquitinates and stabilizes TbetaRII."

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"Together, these data suggest that deubiquitination of TGFBR2 by USP11 effectively spares TGFBR2 from proteasomal degradation to promote EMT and metastasis."

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"Usp11 promotes the development of renal fibrosis by deubiquitinating Tgfbr2, reducing Tgfbr2 ubiquitination degradation, and then facilitating the activation of downstream senescent signaling pathway."

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"We demonstrate that knockdown of USP11 increases the ubiquitination of TbetaRII, whereas overexpression of USP11 greatly decreases ubiquitination of TbetaRII."

"Together, these data suggest that deubiquitination of TGFBR2 by USP11 effectively spares TGFBR2 from proteasomal degradation to promote EMT and metastasis."

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"We conducted Co-IP experiments, which revealed that Usp11 was able to interact with Tgfbr2, and inhibition of Usp11 increased the ubiquitination of Tgfbr2."
Modified USP11 leads to the deubiquitination of TGFBR2. 2 / 2
| 2

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"We demonstrate that knockdown of USP11 increases the ubiquitination of TbetaRII, whereas overexpression of USP11 greatly decreases ubiquitination of TbetaRII."

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"Overexpression of USP11 reduces TbetaRII ubiquitination and increases TbetaRII stabilization, thereby elevating phosphorylation of SMAD2/3 and the ultimate expression of FN and SMA."
USP11 affects NFKBIA
1 | 7
USP11 deubiquitinates NFKBIA. 7 / 7
1 | 6

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"Once it is ubiquitinated, IkappaBalpha can be deubiquitinated by its associated USP11 in collaboration with USP15 to prevent excessive NF-kappaB activation induced by TNFalpha."

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"In this assay, we found that USP11-WT but not -C318A mutant abrogated ubiquitination of Flag-IkappaBalpha (XREF_FIG)."

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"In this assay, we found that only USP11 full-length wild type abrogated ubiquitination of Flag-IkappaBalpha (XREF_FIG)."

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"However, we found that overexpression of USP11 C318A mutant only partially rescued the inhibitory effect of USP11-WT on TNFalpha induced IkappaBalpha ubiquitination (XREF_SUPPLEMENTARY) as well as TNFalpha- and IKKbeta induced NF-kappaB activation (XREF_SUPPLEMENTARY)."

"Moreover, knockdown of USP11 expression enhances TNFalpha-induced IkappaBalpha ubiquitination and NF-kappaB activation."

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"Subsequently we analyzed the effect of USP11 knockdown on the TNFalpha induced IkappaBalpha ubiquitination and NF-kappaB activation."

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"These results demonstrate that USP11 deubiquitinates IkappaBalpha."
Modified USP11 leads to the deubiquitination of NFKBIA. 1 / 1
| 1

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"Overexpression of USP11 inhibits IkappaBalpha ubiquitination."
USP11 affects PALB2
1 | 5
USP11 deubiquitinates PALB2. 6 / 6
1 | 5

"PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11"

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"USP11 deubiquitinates PALB2 and promotes BRCA1, PALB2, and BRCA2 complex formation."

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"If USP11 antagonizes PALB2 ubiquitylation by CRL3-KEAP1, then removal of KEAP1 (or CUL3) should reverse the phenotypes imparted by loss of USP11."

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"These mechanisms might be of therapeutic importance in cancer, because defective HR renders cells susceptible to inhibition of base excision repair (BER) mediated by poly (ADP-ribose) polymerase 1 (PARP1) XREF_BIBR - XREF_BIBR : the deubiquitylating enzyme (DUB) ubiquitin carboxyl-terminal hydrolase 11 (USP11) deubiquitylates partner and localizer of BRCA2 (PALB2) during S and G2 phases following DNA damage, allowing the formation of the BRCA1, PALB2, and BRCA2 complex and HR repair to advance in these phases of the cell cycle 64."

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"USP11 (Ubiquitin specific peptidase 11) deubiquitinates PALB2 ubiquitination to promote HR repair."

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"Since recombinant USP11 can de-ubiquitylate PALB2 (1-103) in vitro (XREF_FIG), these results suggest that USP11 promotes the assembly of the BRCA1, PALB2, and BRCA2 complex by reversing the inhibitory ubiquitylation on the PALB2 Lys20/25/30 residues."
USP11 affects LPAR1
1 | 5
USP11 deubiquitinates LPAR1. 6 / 6
1 | 5

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"The stability of lysophosphatidic acid receptor 1 (LPA1) is up-regulated by ubiquitin-specific protease 11 (USP11), which deubiquitinates LPA1 and enhances LPA1-mediated proinflammatory effects [33,36,37,38,39]."

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"3.4 Deubiquitination of LPA1 by USP11 Increases its Stability."

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"Taken together, USP11 deubiquitinates and stabilizes LPA1, and LPA induced switching LPA1 association with USP11 to Nedd4L plays a critical role in LPA1 ubiquitination and degradation (XREF_FIG e)."

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"The stability of LPA1 is up-regulated by ubiquitin specific protease 11 (USP11), which deubiquitinates LPA1 and enhances LPA1 mediated pro inflammatory effects."

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"USP11 reverses LPA1 ubiquitination, thereby stabilizing LPA1 and promoting LPA/LPA1-mediated signaling pathways and inflammatory responses [62]."

"The stability of LPA1 is up-regulated by ubiquitin-specific protease 11 (USP11), which deubiquitinates LPA1 and enhances LPA1-mediated pro-inflammatory effects."
USP11 affects BRCA2
1 | 5
USP11 deubiquitinates BRCA2. 6 / 6
1 | 5

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"USP11 was shown to interact with and deubiquitinates BRCA2 and as well counteracts RNF4 induced SUMO-ubiquitin hybrid chains, suggesting the pleiotropic roles at DSBs sites [XREF_BIBR]."

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"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."

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"While BRCA2 could be deubiquitinated by USP11 in transient overexpression assays, a catalytically inactive USP11 mutant had no effect on BRCA2 ubiquitination or protein levels."

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"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."

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"Although when overexpressed USP11 can deubiquitinate BRCA2 in vivo, it does not antagonize the MMC-induced ubiquitination and degradation of BRCA2 [185]."
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USP11 affects TP53
1 | 1 3
USP11 deubiquitinates TP53. 5 / 5
1 | 1 3

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"USP11 regulates p53 stability by deubiquitinating p53."

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"Similarly, it was found that USP11 deubiquitylates p53 in response to genotoxicity induced by etoposide."

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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."

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"The above results convinced us that USP11 could deubiquitinate and stabilize p53 in microglial cells to repress KLF2 transcription."
USP11 affects mgl-1
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USP11 deubiquitinates mgl-1. 3 / 3
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"Endogenous depletion of RanBPM inhibited the stabilizing action of USP11 on Mgl-1, indicating the crucial role of RanBPM in controlling the deubiquitination of Mgl-1 by USP11."

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"With the presence of RanBPM, USP11 deubiquitinates Mgl-1 to stabilize, indicating that RanBPM is essential for Mgl-1 stabilization."

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"USP11 deubiquitinates and stabilizes Mgl-1 protein."
Modified USP11 leads to the deubiquitination of mgl-1. 1 / 1
| 1

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"The result showed that dose dependent expression of USP11 gradually decreased the level of Mgl-1 ubiquitination."
| 4
USP11 deubiquitinates Nucleoproteins. 3 / 3
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"The result showed that both USP10 and USP11 specifically co-precipitated with NP-HA (lanes 1, 3 and 4, lower panel), consistent with the published result, and NP could be deubiquitinated by only USP11 but not USP10 (lanes 3 and 4, upper panel)."

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"(B) Deubiquitination of NP by cellular USP11 may lower its binding affinity to cRNA."

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"These results combined suggest that USP11 inhibits viral RNA replication through deubiquitinating NP."
USP11 deubiquitinates Nucleoproteins on K187. 1 / 1
| 1

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"Moreover, USP11 deubiquitinated mono-ubiquitination at K187 residue on the influenza NP protein, leading to inhibition of influenza virus RNA replication [84]."
USP11 affects NONO
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USP11 deubiquitinates NONO. 4 / 4
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"Conversely, USP11 silencing with two independent shRNAs increased endogenous NONO poly-ubiquitination in A375 and SK-Mel28."

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"Overexpression of WT-USP11, but not mutant USP11, reduced NONO ubiquitination."

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"30 Here, we further revealed that NONO ubiquitination could be reversed by USP11 to avoid its degradation through the ubiquitin-proteasome pathway."

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"3.4 USP11 deubiquitinates NONO."
USP11 affects KLF4
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USP11 deubiquitinates KLF4. 4 / 4
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"25 , 26 , 27 Recently, USP11 was shown to promote HCC development, 28 but the underlying molecular mechanisms involved in this pathogenic process remain poorly understood.In this study, we used a proteomic approach to identify KLF4‐interacting DUBs and firstly discovered that USP11 was responsible for deubiquitinating KLF4 in HCC cells."

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"These results demonstrate that the ID domain of KLF4 and the catalytic domain of USP11 are responsible for KLF4USP11 interaction.Next, we investigated whether USP11 could deubiquitinate KLF4 as a DUB."

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"USP11 deubiquitinates K63‐dependent polyubiquitination of KLF4 and suppresses its stability."

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"The results suggested that coexpression of USP11 and KLF4 significantly prevented the ubiquitination of KLF4 mediated by WT‐Ub, but not from KO‐Ub (Figure 2A)."
USP11 affects H2AX
1 | 3
USP11 deubiquitinates H2AX. 4 / 4
1 | 3

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"USP11 deubiquitinates H2AX, opposing the ubiquitinating activity of the RNF8 and RNF168 complex."

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"USP11 also functions in DSB repair, wherein USP11 deubiquitinates H2AX to regulate the recruitment of RAD51 and 53BP1 to damage foci."

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"Mechanistically, USP11 interacts with and deubiquitinates γH2AX [33]."
USP11 affects XPC
1 | 2
USP11 deubiquitinates XPC. 3 / 3
1 | 2

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"Regulation of XPC deubiquitination by USP11 in repair of UV induced DNA damage."

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"USP11 knockdown in HaCaT cells increased ubiquitination of XPC as compared to control cells, suggesting that USP11 is important in maintaining NER capacity, as USP11 mediates XPC deubiquitination at the chromatin following UVB damage [XREF_BIBR]."

"Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage"
USP11 affects XIAP
1 | 2
USP11 deubiquitinates XIAP. 3 / 3
1 | 2

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"3.5 Identification of Molecular Motifs on USP11 and XIAP that Mediate Deubiquitylation of XIAP by USP11."

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"Our identification of deubiquitylation of XIAP by USP11 adds up a novel layer for XIAP regulation."
USP11 affects USP11
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USP11 deubiquitinates USP11. 3 / 3
| 3

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"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."

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"Since USP11 is known to auto-deubiquitylate , it is plausible that ectopic USP11 could deubiquitylate endogenous USP11 leading to increased stability."

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"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
USP11 affects RAE1
1 | 2
USP11 deubiquitinates RAE1. 3 / 3
1 | 2

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"USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation."

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"We show here that deubiquitination of RAE1 by USP11 does not regulate RAE1 protein levels nor the SAC."

"USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation."
USP11 affects PRMT1
| 3
USP11 deubiquitinates PRMT1. 3 / 3
| 3

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"We also find that USP11 deubiquitylates PRMT1 and that this correlates with an increase in the methylation of the PRMT1 substrate MRE11."

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"More interestingly, we did indeed identify USP11 as a PRMT1 DUB because knockdown of USP11 increased PRMT1 ubiquitylation, whilst ectopic overexpression suppressed ubiquitylation in a USP11 catalytic-dependent manner (Fig. 7b and Supplementary Fig. 5b)."

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"USP11 deubiquitylation of PRMT1 regulates methyltransferase activity."
USP11 affects PRC1
1 | 2
USP11 deubiquitinates PRC1. 3 / 3
1 | 2

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"In some cancer types, PRC1 can be deubiquitinated by USP7, USP11 and USP26 [XREF_BIBR, XREF_BIBR]."

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"Lastly, USP7 and USP11 deubiquitinate PRC1, a protein found to contribute to cancer stemness [XREF_BIBR - XREF_BIBR]."
USP11 affects EIF4B
| 3
USP11 deubiquitinates EIF4B. 2 / 2
| 2

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"Furthermore, while embarking on the molecular characterization, we noted that USP11 in a FASN-S6kinase dependent manner deubiquitinates eIF4B to enhance its protein level(11)."

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"Next, to demonstrate whether USP11 can directly deubiquitinate eIF4B, we performed in vitro deubiquitinase assays."
USP11 deubiquitinates EIF4B on aspartic acid. 1 / 1
| 1

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"Remarkably, assessing deubiquitination levels of eIF4B in cell based assays we found that USP11 (wt and Asp mutant) was able to deubiquitinate eIF4B compared with GFP transfected cells, which did not occur for USP11 S453A."
USP11 affects CDKN1A
| 3
USP11 deubiquitinates CDKN1A. 3 / 3
| 3

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"As a result, USP11 reverses p21 polyubiquitylation and degradation mediated by SCF SKP2, CRL4 CDT2, and APC/C CDC20 in a cell-cycle-independent manner."

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"For instance, USP11 can reverse the ubiquitination and degradation of p21, a cyclin-dependent kinase inhibitor, and hence mediate the DNA damage response and apoptosis."

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"Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses."
USP11 affects TGFbeta receptor
| 2
USP11 deubiquitinates TGFbeta receptor. 2 / 2
| 2

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"For example, the closely related DUBs USP4, USP11 and USP15 have been reported to modulate TGFbeta signalling by deubiquitylating the type I TGFbeta receptor ALK5 [XREF_BIBR - XREF_BIBR]."

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"USP11 interacts with and deubiquitylates the type I TGFbeta receptor (ALK5), resulting in enhanced TGFbeta induced gene transcription."
USP11 affects TGFB
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USP11 deubiquitinates TGFB. 2 / 2
| 2

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"USP11 interacts with and deubiquitylates the type I TGFbeta receptor (ALK5), resulting in enhanced TGFbeta induced gene transcription."

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"For example, the closely related DUBs USP4, USP11 and USP15 have been reported to modulate TGFbeta signalling by deubiquitylating the type I TGFbeta receptor ALK5 [XREF_BIBR - XREF_BIBR]."
USP11 affects SUMO-ubiquitin chains
| 2
USP11 deubiquitinates SUMO-ubiquitin chains. 2 / 2
| 2

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"USP11 also deubiquitinates SUMO-ubiquitin chains from PML, while the sumolytion of LPA1 has not been discovered."

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"USP11 can deubiquitinate hybrid SUMO-ubiquitin chains to counteract RNF4."
USP11 affects SOX11
| 2
USP11-R241Q leads to the deubiquitination of SOX11. 1 / 1
| 1

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"Accordingly, the Usp11 R241Q mutant failed to reduce Sox11 ubiquitination level when overexpressed in cells (XREF_FIG)."
USP11 deubiquitinates SOX11. 1 / 1
| 1

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"Mechanistically, we show that Usp11 deubiquitinates Sox11, which is critical for Sox11 stabilization during cortical development."
USP11 affects SNAI1
| 2
USP11 leads to the deubiquitination of SNAI1. 2 / 2
| 2

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"Our results revealed that USP11 promoted EMT in ovarian cancer by deubiquitinating Snail, and USP11 may be a novel therapeutic target for ovarian cancer treatment."

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"Upregulation of USP11 promotes epithelial-to-mesenchymal transition by deubiquitinating Snail in ovarian cancer."
USP11 affects PTEN
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USP11 deubiquitinates PTEN. 2 / 2
| 2

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"Mechanistically, USP11 deubiquitinates PTEN to increase its stability, which promotes the inhibition of PI3K signalling 50."

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"Furthermore, depletion of USP11 by siRNAs attenuated the lnc-DILC-induced deubiquitination of PTEN (Fig. 6c)."
USP11 affects PCGF2
| 2
USP11 deubiquitinates PCGF2. 2 / 2
| 2

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"Nevertheless, MEL18 and BMI were deubiquitylated by USP7 and USP11, two chromatin bound components of polycomb and repressive complex 1 complex components that influence the transcriptional regulation of p16INK4a [XREF_BIBR]."

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"Importantly, over-expression of HA tagged USP7 or USP11 reduced the overall ubiquitination of MEL18 (XREF_FIG, lanes 2 and 4)."
USP11 affects NFkappaB
| 2
USP11 leads to the deubiquitination of NFkappaB. 1 / 1
| 1

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"Subsequently we analyzed the effect of USP11 knockdown on the TNFalpha induced IkappaBalpha ubiquitination and NF-kappaB activation."
Modified USP11 leads to the deubiquitination of NFkappaB. 1 / 1
| 1

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"Furthermore, knockdown of USP11 expression enhanced TNFalpha mediated IkappaBalpha ubiquitination and NF-kappaB activation but had no effect on TNFalpha mediated MAPK activation."
USP11 affects Histone_H2B
| 2
USP11 deubiquitinates Histone_H2B on K120. 1 / 1
| 1

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"Although the function of USP11 in DSB repair will be discussed below, recently it is reported that USP11 directly and specifically deubiquitylates gammaH2AX, but not H2A (K119) and H2B (K120) in vitro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
USP11 leads to the deubiquitination of Histone_H2B. 1 / 1
| 1

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"In line with this, USP11 co-purifies with the NuRD chromatin remodelling complex promoting H2A/H2B deubiquitylation and timely disassembly of DNA repair factors ."
USP11 affects E2F1
1 | 1
USP11 deubiquitinates E2F1. 2 / 2
1 | 1

"Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells"

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"Additionally, it has also been reported that GSK3β increases the interaction of E2F1 with USP11, which results in the deubiquitination and stabilization of E2F1, which in turn activates PEG10 expression to promote proliferation in A549 [33]."
USP11 affects hybrid SUMO2-ubiquitin chains
| 1
USP11 deubiquitinates hybrid SUMO2-ubiquitin chains. 1 / 1
| 1

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"In vitro experiments showed that USP11 was able to deubiquitinate hybrid SUMO2-ubiquitin chains produced by RNF4."
USP11 affects VGLL4
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USP11 deubiquitinates VGLL4. 1 / 1
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"In this study, we identify deubiquitinating enzyme USP11 as a novel VGLL4 interactor."
USP11 affects USP9X
| 1
USP11 deubiquitinates USP9X. 1 / 1
| 1

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."
USP11 affects USP15
| 1
USP11 deubiquitinates USP15. 1 / 1
| 1

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."
USP11 affects SMAD7
| 1
USP11 deubiquitinates SMAD7. 1 / 1
| 1

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."
USP11 affects SMAD4
| 1
USP11 deubiquitinates SMAD4. 1 / 1
| 1

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."
USP11 affects RNF4
| 1
USP11 leads to the deubiquitination of RNF4. 1 / 1
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"Remarkably, USP11 was able to antagonize RNF4- and Roc1-Cul3-KLHL20-mediated PML ubiquitination in 293T cells and GBM cell line U87 (XREF_SUPPLEMENTARY)."
USP11 affects RANBP9
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USP11 deubiquitinates RANBP9. 1 / 1
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USP11 affects PPP1CA
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USP11 deubiquitinates PPP1CA. 1 / 1
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"Mechanically, USP11 stabilized PPP1CA by deubiquitinating and protecting it from proteasome-mediated degradation."
USP11 affects NFE2L2
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USP11 deubiquitinates NFE2L2. 1 / 1
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"We further found that USP11 deubiquitinates NRF2; this modification stabilizes NRF2."
USP11 affects LCK
| 1
USP11 deubiquitinates LCK. 1 / 1
| 1

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"USP11 forms a complex with USP7 to deubiquitinate the oncogenic lymphocyte cell-specific protein-tyrosine kinase (LCK) and enhance its activity."
USP11 affects ILF3
| 1
USP11 deubiquitinates ILF3. 1 / 1
| 1

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"Collectively, the present findings indicated that USP11 binded to and deubiquitinated NF90, thereby stabilizing the protein expression level and promoting HCC cell proliferation and metastasis."
USP11 affects IL6
| 1
USP11 leads to the deubiquitination of IL6. 1 / 1
| 1

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"In addition, USP11 also inhibited IL-6 degradation by affecting IL-6 ubiquitination."
USP11 affects IKBKB
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USP11 deubiquitinates IKBKB. 1 / 1
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"Both USP11 and USP15 also negatively regulate and function by deubiquitinating IκB to sequester NFκB in the cytoplasm."
USP11 affects HDAC2
| 1
USP11 deubiquitinates HDAC2. 1 / 1
| 1

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"In contrast, USP11 failed to deubiquitinate HDAC2 (XREF_FIG)."
USP11 affects E7
| 1
USP11 deubiquitinates E7. 1 / 1
| 1

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"USP-11 deubiquitylates specific substrates which play key roles in correct microtubule nucleation (RanBPM) [XREF_BIBR]; antigen presenting cell function (RELB) [XREF_BIBR]; inflammation, immunity, cell proliferation and apoptosis (TNFa induced NK-kB, and IKKa and p53 signaling pathway) [XREF_BIBR, XREF_BIBR]; and E7 modulated cell growth and transformation (HPV-16E7) [XREF_BIBR]."
USP11 affects CYLD
| 1
USP11 deubiquitinates CYLD. 1 / 1
| 1

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."
USP11 affects CHUK
1 |
USP11 deubiquitinates CHUK. 1 / 1
1 |
USP11 affects CDKN
| 1
USP11 leads to the deubiquitination of CDKN. 1 / 1
| 1

reach
"For instance, USP11 can reverse the ubiquitination and degradation of p21, a cyclin-dependent kinase inhibitor, and hence mediate the DNA damage response and apoptosis."
USP11 affects BMI1
1 |
USP11 deubiquitinates BMI1. 1 / 1
1 |
USP11 affects BECN1
| 1
USP11 deubiquitinates BECN1. 1 / 1
| 1

reach
"USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1."