IndraLab

Statements


USP11 deubiquitinates PML. 9 / 10
1 | 1 8

reach
"USP11 deubiquitinates PML."

reach
"USP11 deubiquitinates and stabilizes PML, thereby counteracting the functions of PML ubiquitin ligases RNF4 and the KLHL20-Cul3 (Cullin 3) and Roc1 complex."

trips
"USP11 deubiquitinates and stabilizes PML, thereby counteracting the functions of PML ubiquitin ligases RNF4 and the KLHL20-Cul3 (Cullin 3)-Roc1 complex."

reach
"Remarkably, USP11 was able to antagonize RNF4- and Roc1-Cul3-KLHL20-mediated PML ubiquitination in 293T cells and GBM cell line U87 (XREF_SUPPLEMENTARY)."

reach
"PML [33], SOX11 [18], VCP [34], and other proteins were also proved to be deubiquitinated by USP11 with uncertain linking type, which further contributed or restrained the progression of different diseases."

reach
"We demonstrated that USP11 deubiquitinates and stabilizes PML."

reach
"Next, we determined whether USP11 could deubiquitinate PML in vitro."

reach
"By contrast, USP11 promotes deubiquitination and stabilization of PML [XREF_BIBR]."

reach
"In brain tumors, USP11 deubiquitinates and stabilizes PML, and its transcription is inhibited by the Notch effector Hey1 ."