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USP11 deubiquitinates NFE2L2. 6 / 7
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"We further found that USP11 deubiquitinates NRF2; this modification stabilizes NRF2."
33531626
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"Moreover, the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2), which plays a crucial role in cancer progression, was deubiquitinated by USP11, and the depletion of USP11 contributes to the suppression of cell proliferation and the induction of ferroptosis [12]."
36612069
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"Similarly, deubiquitination of NRF2 by USP11 has been shown to stabilize NRF2 signaling in cell lines and in the context of tumors [67] and to deubiquitinase the TGF-βR1 and thereby enhance TGF-β signaling [68]."
37874479
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"Ubiquitin-specific-processing protease 11 deubiquitinates and stabilizes NRF2, which contributes to the suppression of ferroptosis (Meng et al., 2021)."
36018155
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"USP11 overexpression could significantly relieve NRF2 ubiquitination and degradation induced by RSL3 treatment of KLK LUAD cells (Figure 6D), suggesting that RSL3 inhibition of NRF2 expression might be through USP11 suppression in KLK LUAD cells."
36358651
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"In contrast, the deubiquitinating enzyme ubiquitin specific peptidase 11 (USP11) reduces cell sensitivity to ferroptosis by deubiquitinating NFE2L2 and stabilizing its expression in lung cancer cells [156]."
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