IndraLab

Statements

USP11 deubiquitinates TGFBR2. 7 / 8
1 | 7
reach
"TGFBR2 is deubiquitinated by USP11 to maintain the TGF-β signal pathway (Jacko et al., 2016) and the glycosylation of TGFBR2 enhances the radio-resistance and BC cell stemness (Sun et al., 2021); therefore, maintaining a normal TGF-β pathway is essential for cancer cell control."
39525474
reach
"The novel finding in this study is that USP11 de-ubiquitinates and stabilizes TbetaRII."
27853171
reach
"We demonstrate that knockdown of USP11 increases the ubiquitination of TbetaRII, whereas overexpression of USP11 greatly decreases ubiquitination of TbetaRII."
27853171
reach
"USP11 de-ubiquitinates and stabilizes TbetaRII."
27853171
reach
"Together, these data suggest that deubiquitination of TGFBR2 by USP11 effectively spares TGFBR2 from proteasomal degradation to promote EMT and metastasis."
29724812
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"We conducted Co-IP experiments, which revealed that Usp11 was able to interact with Tgfbr2, and inhibition of Usp11 increased the ubiquitination of Tgfbr2."
36045219
reach
"Usp11 promotes the development of renal fibrosis by deubiquitinating Tgfbr2, reducing Tgfbr2 ubiquitination degradation, and then facilitating the activation of downstream senescent signaling pathway."
36045219