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USP11 deubiquitinates NFKBIA. 7 / 7
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"Once it is ubiquitinated, IkappaBalpha can be deubiquitinated by its associated USP11 in collaboration with USP15 to prevent excessive NF-kappaB activation induced by TNFalpha."
19874889
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"In this assay, we found that USP11-WT but not -C318A mutant abrogated ubiquitination of Flag-IkappaBalpha (XREF_FIG)."
19874889
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"In this assay, we found that only USP11 full-length wild type abrogated ubiquitination of Flag-IkappaBalpha (XREF_FIG)."
19874889
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"However, we found that overexpression of USP11 C318A mutant only partially rescued the inhibitory effect of USP11-WT on TNFalpha induced IkappaBalpha ubiquitination (XREF_SUPPLEMENTARY) as well as TNFalpha- and IKKbeta induced NF-kappaB activation (XREF_SUPPLEMENTARY)."
19874889
ubibrowser
"Moreover, knockdown of USP11 expression enhances TNFalpha-induced IkappaBalpha ubiquitination and NF-kappaB activation."
19874889
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"Subsequently we analyzed the effect of USP11 knockdown on the TNFalpha induced IkappaBalpha ubiquitination and NF-kappaB activation."
19874889
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"These results demonstrate that USP11 deubiquitinates IkappaBalpha."
19874889