IndraLab

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USP11 deubiquitinates PALB2. 8 / 9
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"If USP11 antagonizes PALB2 ubiquitylation by CRL3-KEAP1, then removal of KEAP1 (or CUL3) should reverse the phenotypes imparted by loss of USP11."
26649820
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"Strikingly, the centromere histone variant CENP-A enables the activation of HR in G1 by mediating the recruitment of the deubiquitinase USP11, which subsequently enables the formation of the RAD51–BRCA1–BRCA2 HR complex by deubiquitinating PALB2 (62) (Figure 2C)."
37180029
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"Since recombinant USP11 can de-ubiquitylate PALB2 (1-103) in vitro (XREF_FIG), these results suggest that USP11 promotes the assembly of the BRCA1, PALB2, and BRCA2 complex by reversing the inhibitory ubiquitylation on the PALB2 Lys20/25/30 residues."
26649820
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"PALB2 ubiquitylation can be reversed by USP11 deubiquitylase, restoring formation of BRCA1-PALB2-BRCA2 complex ( Fig. 4 B)."
30586619
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"USP11 (Ubiquitin specific peptidase 11) deubiquitinates PALB2 ubiquitination to promote HR repair."
28552167
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"USP11 deubiquitinates PALB2 and promotes BRCA1, PALB2, and BRCA2 complex formation."
33567341
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"These mechanisms might be of therapeutic importance in cancer, because defective HR renders cells susceptible to inhibition of base excision repair (BER) mediated by poly (ADP-ribose) polymerase 1 (PARP1) XREF_BIBR - XREF_BIBR : the deubiquitylating enzyme (DUB) ubiquitin carboxyl-terminal hydrolase 11 (USP11) deubiquitylates partner and localizer of BRCA2 (PALB2) during S and G2 phases following DNA damage, allowing the formation of the BRCA1, PALB2, and BRCA2 complex and HR repair to advance in these phases of the cell cycle 64."
29242641
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"For example, USP11 recruits BRCA1 to chromatin by deubiquitinating PALB2 (partner and localizer of BRCA2) in a cell cycle-dependent manner or stabilizing MYCN in neuroblastoma ."
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