IndraLab

Statements

USP11 deubiquitinates PALB2. 6 / 6
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"PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11"
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"USP11 deubiquitinates PALB2 and promotes BRCA1, PALB2, and BRCA2 complex formation."
33567341
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"If USP11 antagonizes PALB2 ubiquitylation by CRL3-KEAP1, then removal of KEAP1 (or CUL3) should reverse the phenotypes imparted by loss of USP11."
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"These mechanisms might be of therapeutic importance in cancer, because defective HR renders cells susceptible to inhibition of base excision repair (BER) mediated by poly (ADP-ribose) polymerase 1 (PARP1) XREF_BIBR - XREF_BIBR : the deubiquitylating enzyme (DUB) ubiquitin carboxyl-terminal hydrolase 11 (USP11) deubiquitylates partner and localizer of BRCA2 (PALB2) during S and G2 phases following DNA damage, allowing the formation of the BRCA1, PALB2, and BRCA2 complex and HR repair to advance in these phases of the cell cycle 64."
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"USP11 (Ubiquitin specific peptidase 11) deubiquitinates PALB2 ubiquitination to promote HR repair."
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"Since recombinant USP11 can de-ubiquitylate PALB2 (1-103) in vitro (XREF_FIG), these results suggest that USP11 promotes the assembly of the BRCA1, PALB2, and BRCA2 complex by reversing the inhibitory ubiquitylation on the PALB2 Lys20/25/30 residues."
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