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USP11 deubiquitinates PTEN. 5 / 5
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"For example, it was found that USP11, which is regulated by FOXO (Park et al., 2019), can act as a regulator of the PTEN/PI3K pathway by deubiquitinating PTEN, thereby enhancing its stability and indirectly inhibiting PI3K signaling (Park et al., 2019)."
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"Furthermore, several DUBs, including HAUSP/USP7, USP10, USP11, USP13, OTUD3, and Ataxin-3 have been shown to reverse the ubiquitination of PTEN, a key antagonist in the PI3K growth-promoting pathway, implicating its function in cancer-specific contexts [15]."
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"In contrast, one study has reported that USP11 deubiquitinates and stabilizes the tumor suppressor PTEN in PCa (21)."
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"Furthermore, depletion of USP11 by siRNAs attenuated the lnc-DILC-induced deubiquitination of PTEN (Fig. 6c)."
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"Mechanistically, USP11 deubiquitinates PTEN to increase its stability, which promotes the inhibition of PI3K signalling 50."
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