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USP11 deubiquitinates NONO. 6 / 6
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"3.4 USP11 deubiquitinates NONO."
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"Overexpression of WT-USP11, but not mutant USP11, reduced NONO ubiquitination."
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"Conversely, USP11 silencing with two independent shRNAs increased endogenous NONO poly-ubiquitination in A375 and SK-Mel28."
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"30 Here, we further revealed that NONO ubiquitination could be reversed by USP11 to avoid its degradation through the ubiquitin-proteasome pathway."
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"USP11 may stimulate tumorigenesis by deubiquitinating cIAP2, NONO, NF90, E2F1, or cytoplasmic p21; however, it may also inhibit tumorigenesis through stabilizing PML, Mgl-1, PTEN, ARID1A, or nuclear p21 (29, 30)."
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"Collectively, these results demonstrate that <span class="match term0">USP11</span> is a new deubiquitinase of <span class="match term1">NONO</span> and that the signalling axis of <span class="match term0">USP11</span>-<span class="match term1">NONO</span> is significantly involved in melanoma proliferation."
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