IndraLab

Statements

USP11 deubiquitinates SPRTN. 9 / 10
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"USP11 mediates repair of DNA protein cross-links by deubiquitinating SPRTN metalloprotease."
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"Neither VCPIP1 nor USP11 induce SPRTN deubiquitylation when overexpressed, while USP7 does (XREF_SUPPLEMENTARY)."
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"USP11 deubiquitinates SPRTN in cells and invitro."
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"To show that deubiquitination of SPRTN by USP11 is direct, we purified SFB-SPRTN, Myc-USP11, and Myc-USP11 C318S proteins from HEK 293T cells and performed an invitro DUB reaction by incubating SFB-SPRTN alone or with Myc-USP11 or Myc-USP11 C318S purified proteins."
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"USP11 deubiquitinates SPRTN upon DPC induction."
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"We observed that USP11, but not USP11 C318S catalytic mutant, deubiquitinated SPRTN (XREF_FIG E, anti-Ub blot) and reduced SPRTN auto-cleavage products (XREF_FIG E, IP blot)."
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"USP11 deubiquitinates SPRTN for the repair of DNA–protein crosslinks and γH2AX for the double-strand-break repair (55, 56)."
39145935
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"However, we observe that lack of SPRTN deubiquitination by USP11 and VCPIP1 did not affect recruitment on chromatin."
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"Upon formaldehyde treatment and other yet to be identified signals, SPRTN is deubiquitinated by USP11 (this study), USP7, and VCPIP1."
33567341