IndraLab

Statements

USP11 deubiquitinates E2F1. 3 / 4
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"USP11 may stimulate tumorigenesis by deubiquitinating cIAP2, NONO, NF90, E2F1, or cytoplasmic p21; however, it may also inhibit tumorigenesis through stabilizing PML, Mgl-1, PTEN, ARID1A, or nuclear p21 (29, 30)."
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"USP11 promotes proliferation and metastasis of hepatocellular carcinoma cells by deubiquitinating and stabilizing E2F1 (19), and USP11 promotes invasion and metastasis of ovarian cancer by deubiquitinating and stabilizing the transcription factor Snail (20)."
39052835
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"Additionally, it has also been reported that GSK3β increases the interaction of E2F1 with USP11, which results in the deubiquitination and stabilization of E2F1, which in turn activates PEG10 expression to promote proliferation in A549 [33]."
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