IndraLab

Statements

USP11 deubiquitinates USP11. 3 / 3
| 3
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."
23712866
reach
"Since USP11 is known to auto-deubiquitylate , it is plausible that ectopic USP11 could deubiquitylate endogenous USP11 leading to increased stability."
34728620
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
23712866