IndraLab

Statements

USP11 deubiquitinates USP11. 3 / 3
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reach
"Since USP11 is known to auto-deubiquitylate , it is plausible that ectopic USP11 could deubiquitylate endogenous USP11 leading to increased stability."
34728620
reach
"Taken together, the data above confirmed that USP11 inhibits Sirt3 degradation through deubiquitinating Sirt3.3.6 USP11 ameliorates ferroptosis, thus relieving IVDD by increasing Sirt3."
37099926
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
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