IndraLab

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USP11 deubiquitinates BRCA2. 6 / 6
1 | 5
reach
"USP11 was shown to interact with and deubiquitinates BRCA2 and as well counteracts RNF4 induced SUMO-ubiquitin hybrid chains, suggesting the pleiotropic roles at DSBs sites [XREF_BIBR]."
28031783
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability : USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C (MMC) regulates the stability of BRCA2 in a USP11 dependent manner [XREF_BIBR]."
23712866
ubibrowser
"Review"
28031783
reach
"While BRCA2 could be deubiquitinated by USP11 in transient overexpression assays, a catalytically inactive USP11 mutant had no effect on BRCA2 ubiquitination or protein levels."
15314155
reach
"Several lines of evidence point towards a critical role for USP11 in regulating BRCA2 stability: USP11 interacts and co-purifies with BRCA2, USP11 deubiquitylates BRCA2, USP11 depletion sensitises cells to DNA damaging agents and finally, mitomycin C(MMC) regulates the stability of BRCA2 in a USP11-dependent manner [117]."
23712866
reach
"Although when overexpressed USP11 can deubiquitinate BRCA2 in vivo, it does not antagonize the MMC-induced ubiquitination and degradation of BRCA2 [185]."
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