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USP11 deubiquitinates PPP1CA. 3 / 4

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"For example, USP11 promotes growth and metastasis of colorectal cancer by deubiquitinating and stabilizing PPP1CA (16)."

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"Ubiquitination assay further revealed that USP11 overexpression significantly inhibited poly-ubiquitination of PPP1CA protein (Fig. 5c)."

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"Mechanically, we revealed that USP11 could activate the ERK/MAPK signaling pathway by deubiquitinating and stabilizing PPP1CA, resulting in the malignant development of CRC."

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USP11 deubiquitinates PPP1CA. 3 / 4

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