IndraLab

Statements

USP11 deubiquitinates H2AX. 6 / 7
1 | 6
reach
"Mechanistically, USP11 interacts with and deubiquitinates γH2AX [33]."
32708614
reach
"USP11 deubiquitinates SPRTN for the repair of DNA–protein crosslinks and γH2AX for the double-strand-break repair (55, 56)."
39145935
reach
"USP11 acts in both H2AK119 and H2BK120 deubiquitination and specifically deubiquitinates the histone variant γH2AX, which is key in homologous recombination , although no epigenomic data is available for the activity of these human proteins."
38253560
reach
"USP11 deubiquitinates H2AX, opposing the ubiquitinating activity of the RNF8 and RNF168 complex."
30831436
reach
"USP11 also functions in DSB repair, wherein USP11 deubiquitinates H2AX to regulate the recruitment of RAD51 and 53BP1 to damage foci."
33567341
reach
"γH2AX can be ubiquitylated by RNF8/RNF168, but deubiquitylated by USP11 [ 126 ]."
37328395