IndraLab

Statements


USP11 deubiquitinates H2AX. 4 / 4
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"USP11 deubiquitinates H2AX, opposing the ubiquitinating activity of the RNF8 and RNF168 complex."

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"USP11 also functions in DSB repair, wherein USP11 deubiquitinates H2AX to regulate the recruitment of RAD51 and 53BP1 to damage foci."

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"Mechanistically, USP11 interacts with and deubiquitinates γH2AX [33]."