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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified USP11 leads to the deubiquitination of TGFBR2. 2 / 2

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"We demonstrate that knockdown of USP11 increases the ubiquitination of TbetaRII, whereas overexpression of USP11 greatly decreases ubiquitination of TbetaRII."

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"Overexpression of USP11 reduces TbetaRII ubiquitination and increases TbetaRII stabilization, thereby elevating phosphorylation of SMAD2/3 and the ultimate expression of FN and SMA."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...