IndraLab

Statements

USP11 deubiquitinates CDKN1A. 7 / 8
1 | 7
reach
"Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses."
29666278
reach
"Recent studies have revealed that USP11 deubiquitinates and stabilizes p21 protein under physiological conditions, as well as in response to DNA damage [17]."
37676377
reach
"We further presumed that RanBPM might promote the interaction between USP11 and p21, and regulate USP11-dependent deubiquitination of p21."
37676377
reach
"Notably, USP11 plays a key role in DNA damage repair depending on its catalytic activity, for example, Xia Ting et al. [20] found that USP11 acts as a histone deubiquitinase in chromatin reorganization during DNA repair, Palak Shah et al. [21] found that USP11 regulates UV-induced DNA damage repair by deubiquitinating XPC, and Tanggang Deng et al. [32] identified that the deubiquitylation and stabilization of p21 by USP11 is essential for cell cycle progression and DNA damage responses."
35715413
reach
"USP11 may stimulate tumorigenesis by deubiquitinating cIAP2, NONO, NF90, E2F1, or cytoplasmic p21; however, it may also inhibit tumorigenesis through stabilizing PML, Mgl-1, PTEN, ARID1A, or nuclear p21 (29, 30)."
39270819
reach
"For instance, USP11 can reverse the ubiquitination and degradation of p21, a cyclin-dependent kinase inhibitor, and hence mediate the DNA damage response and apoptosis."
34141823
reach
"As a result, USP11 reverses p21 polyubiquitylation and degradation mediated by SCF SKP2, CRL4 CDT2, and APC/C CDC20 in a cell-cycle-independent manner."
29666278