IndraLab

Statements

USP11 deubiquitinates CDKN1A. 3 / 3
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"As a result, USP11 reverses p21 polyubiquitylation and degradation mediated by SCF SKP2, CRL4 CDT2, and APC/C CDC20 in a cell-cycle-independent manner."
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"For instance, USP11 can reverse the ubiquitination and degradation of p21, a cyclin-dependent kinase inhibitor, and hence mediate the DNA damage response and apoptosis."
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"Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses."
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