IndraLab

Statements


USP11 deubiquitinates TGFBR1. 10 / 10
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"USP11 deubiquitylates ALK5."

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"It has been revealed that the DUBs, UCH37, USP11, and USP15, de-ubiquitinate and stabilize TbetaRI."

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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR In this study, we show that USP11 has no effect on TbetaRI stability in human lung fibroblast cells, though Al-Salihi et al. 21 showed that USP11 de-ubiquitinates TbetaRI."

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"USP11 augments TGFbeta signalling by deubiquitylating ALK5."

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"USP11 was able to reduce ALK5 polyubiquitylation, although not to basal levels."

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"UCHL37, USP11, and USP15 de-ubiquitinate TbetaRI, XREF_BIBR, XREF_BIBR, XREF_BIBR while USP15, CYLD, and USP9X target SMAD4 or SMAD7."

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"For example, the closely related DUBs USP4, USP11 and USP15 have been reported to modulate TGFbeta signalling by deubiquitylating the type I TGFbeta receptor ALK5 [XREF_BIBR - XREF_BIBR]."

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"Over-expressed wt USP11 was able to deubiquitylate ALK5."

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"Likely, USP11 is also involved in the TGF/BMP signaling pathway by deubiquitylating ALK5 [98]."