IndraLab

Statements

USP7 affects TP53
2 54 2 1 | 12 1 579 247
USP7 binds TP53.
54 2 | 1 133 242
TP53 binds USP7. 10 / 363
54 2 | 1 116 169
sparser
"RORα promotes interactions between p53 and USP7 but does not affect interactions between p53 and MDM2 (ref. xref )."
25283148
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"HAUSP interacted with and deubiquitinated p53, leading to increased p53 levels."
15916963
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"It has been reported that the EBNA1 protein binds to USP7 with high affinity and impairs the interaction of p53 and USP7."
36624687
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"The interaction between p53 and USP7 can be disrupted by EBNA1."
33505922
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"USP7 binds to and directly deubiquitinates p53 and inhibits its degradation."
36624687
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"Interest in USP7 was renewed by the observation that USP7 binds to the C-terminal domain of p53, promotes its de-ubiquitination and subsequent stabilization [24] ."
17961905
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"USP7 was also shown to be involved in the stress-induced p53 translocation to the mitochondria since a stress-inducible USP7-p53 complex was formed at the mitochondria resulting in p53 de-ubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961905
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"It has been reported that the EBNA1 protein binds to USP7 with high affinity and impairs the interaction of p53 and USP7."
36624687
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"USP7 binds to and directly deubiquitinates p53 and inhibits its degradation."
36624687
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"32 In response to DNA damage, HAUSP interacts with p53, causing its stabilization."
25843733
USP7 binds TP53 and MDM2. 10 / 50
| 14 36
sparser
"In a similar experiment, alanine substitutions of NTD residues known to be important for interactions of USP7 substrates such as p53 and MDM2 ( xref , xref ) led to loss of (W 149 A and DWGFS 152 A 5 ) or greatly diminished (R 88 A) interaction of the residue 1 to 220 USP7 fragment with vIRF-2 (data not shown), indicating canonical interaction of the vIRF-2 PSTS motif with the USP7 TRAF-like domain despite the additional requirements for vIRF-2 and its binding region (residues 241 to 260) to interact with USP7."
31666375
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"For example, USP7 (HAUSP) interacts with MDM2 to regulate the turnover of p53 together, and it is also able to increase the stability of MDM2 xref ."
24714733
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"The Protein Data Bank () accession numbers for the atomic coordinates of the HAUSP TRAF-like domain alone, the HAUSP TRAF-like domain bound to p53 and MDM2 peptides, and HAUSP (residues 53–560) are 2F1W, 2F1X, 2F1Y, and 2F1Z, respectively."
16402859
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"We show that the N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2, falling between p53 residues 359-367 and MDM2 residues 147-159."
16474402
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"Moreover, p53 was found to be upregulated in MDM2 −/− p53 −/− double-deficient MEFs after co-transfection of both p53 and ABRO1, indicating that ABRO1-dependent p53 stabilization is made possible by enhanced p53-USP7 interaction without effects on p53-MDM2 interaction and MDM2 stability."
25283148
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"The accumulated evidence regarding the interactions of USP7 and MDM2 with p53 indicates that these interactions are important in regulating the stability of p53 under both physiological and pathological conditions."
25283148
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"Structural studies have shown that p53 and MDM2 interact with the N-terminus of USP7 in a mutually exclusive manner [ xref ]."
23151129
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"Taken together, the activation of USP7-MDM2-p53 interaction can promote the occurrence and development of tumors."
31114498
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"19 The identification of Nucleolin as a substrate of HAUSP and a member of the HAUSP, p53, and MDM2 complex has added to the complexity of its dynamics, implicating cellular adaptations to combat DNA damage stress by upregulating Nucleolin in the presence of ionizing radiation."
29967688
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"The N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2 (p53 residues 359−367 and MDM2 residues 147−159) ( xref )."
19489724
BAG6 binds USP7 and TP53. 3 / 3
| 3
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"Immunoprecipitation of protein extracts with anti-p53 antibody and subsequent immunoblot analysis revealed a trimeric protein interaction between p53, Bat3 and HAUSP as both HA-Bat3 and Flag-HAUSP were detected in the p53-immunoprecipitated complex ( xref )."
31647545
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"These results suggest that the formation of p53–HAUSP–Bat3 complex may prevent p53 from being recognized and binding to its proteasome receptor S5a, subsequently leading to the accumulation and stabilization of p53 in nucleus ( xref ) though we still do not know whether there is conformational change in Bat3 and p53 at present."
31647545
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"Notably, we revealed that a p53–HAUSP–Bat3 trimeric protein complex could exist in vivo with HAUSP serving as a binding mediator for enhanced interaction between p53 and Bat3, which antagonizes the interaction of p53 with its proteasome receptor S5a and promotes the accumulation of p53 in the nucleus."
31647545
USP7 binds TP53 and EBNA1. 3 / 3
| 3
sparser
"The results of these experiments demonstrated that the deletion of Ubl2 did not inhibit the interaction of USP7 with p53 or EBNA1 ( xref , A and B )."
32587091
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"NMR studies of USP7 bound by EBNA1 and p53 indicated that p53 and EBNA bind the same pocket but p53 but makes less extensive contacts with USP7."
19489724
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"Crystal structure analysis showed that USP7 binds to its substrate p53 and its inhibitory interactor Epstein–Barr nuclear antigen 1 (EBNA1) protein through the same pocket but the former binding partner p53 exhibit weaker contacts with USP7 [ xref , xref ]."
28031783
TP53 binds USP7 and USP10. 2 / 2
| 2
sparser
"For example, USP7 and USP10 bind to and deubiquitylate their substrate p53 to mediate its role for suppression of cell propagation upon cellular stresses by counteracting its degradation xref – xref ."
31745110
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"Using a quantitative mass spectrometry approach and focusing on ubiquitin ligases and proteases, we were able to determine that the interaction between p53 and two DUBs, USP7 and USP10, was reduced under DMOG treatment ( xref A)."
30067985
GMPS binds USP7 and TP53. 2 / 2
| 2
sparser
"Considering that the interaction among GMPS, USP7 with p53 is required for the deubiquitination and stabilization of p53 [ xref , xref ]. we next determined the interaction of GMPS and USP7 with p53 in the p53wt breast cancer cell lines MCF-7 and DU4475 by co-IP assays."
33742136
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"In the context of X-ray radiation, GMPS bound both USP7 and TP53 (Fig. xref b), and TP53 protein levels were elevated upon GMPS overexpression (Additional file xref : Figure S1e), suggesting that GMPS promotes TP53 protein stability."
32005234
MDM2 binds TP53, WRAP53, and USP7. 2 / 2
| 2
sparser
"Taken together, our findings reveal a novel role of WDR79 in the proliferation of NSCLC cells and could pinpoint a new mechanism by which WDR79 and USP7 functionally interact to modulate the Mdm2-p53 pathway."
28406480
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"In this study, we report a new molecular process in which WDR79 interacts with USP7 to modulate the stability of Mdm2 and p53, which promotes the proliferation of NSCLC cells."
28406480
USP7 binds TRAF and TP53. 2 / 2
| 2
sparser
"As shown in xref , p53 has 393 amino acid residues that can be subdivided into five domains: the N-terminal transactivation domains (TAD) that are responsible for its binding to the p53-binding sites on MDM2 and MDMX, a proline-rich region (PP) that contains five PxxP motifs and is essential for inducing apoptosis, a DNA-binding domain (DBD), a tetramerization domain (TET), and a C-terminal domain (CTD) that is critical for the binding of p53 to the TRAF domain of USP7 ( xref ; xref )."
32300595
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"On one hand, p53 binds to TRAF domain and C-terminal (amino acids 880–1050) of USP7, and then USP7 ubiquitinates p53 directly and prevents it from degradation."
31114498
DAXX binds USP7, MDM2, and TP53. 2 / 2
| 1 1
sparser
"Although the molecular mechanism for the interactions of DAXX, HAUSP, Mdm2, and p53 underlying this regulatory pathway are largely unknown, an important clue is provided by our observation that, at le[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The most significant binding partners identified to interact with the C1 domain are the TNF-R1 and TRAIL-R1 -- Modulator of Apoptosis-1 (MOAP-1) complexes and the MDM2, DAXX, HAUSP, and p53 complex [XREF_BIBR, XREF_BIBR] (XREF_FIG)."
22577550
ELP2 binds MDM2, TP53, and USP7. 2 / 2
| 2
sparser
"Considering that the effect of STIP on Mdm2 or p53 was independent of each other, we hypothesize that STIP may associate with the USP7-Mdm2 or USP7-p53 complexes."
26460617
sparser
"These data indicated that STIP may simultaneously bind to USP7 and either Mdm2 or p53, mediating the assembly of ternary STIP-USP7-Mdm2 and STIP-USP7-p53 complexes, respectively."
26460617
USP7 binds NCL, TP53, and MDM2. 2 / 2
| 2
sparser
"We next verified that HAUSP and nucleolin could form a complex with p53 and Mdm2 by examining the interaction between HAUSP and nucleolin in p53- and Mdm2-depleted cells."
26238070
sparser
"Moreover, p53 also could not interact with HAUSP and nucleolin in Mdm2-depleted cells ( xref )."
26238070
ABRAXAS2 binds USP7 and TP53. 2 / 2
| 2
sparser
"Based on the results showing association of ABRO1, p53 and USP7, we presumed that ABRO1 might promote interaction between USP7 and p53, and regulate USP7-dependent deubiquitination of p53."
25283148
sparser
"ABRO1 forms a complex with USP7 and p53."
25283148
TP53 binds USP7 and NCL. 1 / 1
| 1
sparser
"We hypothesized that Mdm2 acts as a mediator between HAUSP and nucleolin in the normal state, and that p53 may be associated with the HAUSP and nucleolin interaction in the DNA damaged condition."
26238070
TP53 binds MDM4 and USP7. 1 / 1
| 1
sparser
"It has also been reported that some SNPs of p53, Mdm2(Murine double minute 2), MdmX and Hausp (Herpes virus-associated ubiquitin-specific protease) in p53 pathway are associated with the risk of the women's reproduction disorder."
22917899
USP7 binds MDM4, MDM2, and TP53. 1 / 1
| 1
sparser
"Further insight into the mechanism by which ATM switches the interactions between HAUSP, Mdmx, Mdm2 and p53, to favor p53 activation may offer new tools for therapeutic intervention in the p53 pathway for cancer treatment."
16082221
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
TP53 binds DAXX and USP7. 1 / 1
| 1
sparser
"MDM2 is a negative regulator of p53 that interacts with DAXX and HAUSP to form tertiary complex (MDM2-DAXX-HAUSP) [ xref ]."
30237857
USP7 binds Ubiquitin, MDM2, and TP53. 1 / 1
| 1
sparser
"USP7 can bind Mdm2 or p53 via its N-terminal and C-terminal regions in a mutually exclusive manner, which consequently stabilizes the two proteins by removing ubiquitin."
28406480
Ubiquitin binds USP7, TRAF, MDM2, and TP53. 1 / 1
| 1
sparser
"The deubiquitinase USP7 binds Mdm2 or p53 via its N -terminal TRAF-domain or C-terminal region in a mutually exclusive manner to remove ubiquitins and stabilize the two proteins [ xref – xref ]."
26460617
USP7 binds TP53 and AKT. 1 / 1
| 1
sparser
"Although the essential role of USPs in protein degradation is well established, less is known about the function and regulation of specific family members: for example Usp7 has been associated with p53 and Akt turnover, Usp8 with receptor tyrosine endocytosis, Usp33 with the Von Hippel–Lindau disease (VHL) pathway and Usp19 is thought to have a role in muscle development [ xref ]."
25886905
TP53 binds DAXX, EBNA1, and USP7. 1 / 1
| 1
sparser
"We identify the ubiquitin-like (Ubl) domain 2 of USP7 as critical for the interaction and deubiquitination of p65 but dispensable for the interaction of USP7 with the USP7 substrates p53, DAXX, and EBNA1."
32587091
USP7 binds MDM2, TP53, and CDKN1A. 1 / 1
| 1
sparser
"In addition to the altered levels of HDM2, p53 and p21 associated with its use, P22077 treatment also caused reduced levels of DNA damage proteins DDB1, RBX1, DCAF7 and DCAF11, all of which are subunits of E3 ligases, indicating a previously unknown functional link between USP7 and enzymes involved in DNA repair [ xref ]."
23822887
USP7 binds ubiquitinated TP53. 1 / 1
| 1
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"USP7 also interacts with the polyubiquitinated p53 and promotes p53 deubiquitination and stability."
20531303
TP53 binds GST, MDM2, NCL, and USP7. 1 / 1
| 1
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"As expected, purified GST-p53 protein could bind Mdm2, nucleolin, and HAUSP ( xref , upper panel)."
26238070
TP53 binds USP7 and FOXO4. 1 / 1
| 1
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"The results of the interaction between the USP7 and FOXO4 in H1299 human lung carcinoma cells that lack p53 suggested that the interaction is p53 independent. xref , xref However, p53 and FOXOs have noticeable similarities such as the ability to stimulate cell-cycle arrest and cell death and they are both regulated by USP7. xref "
35005106
USP7 binds TP53 and GST. 1 / 1
| 1
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"To confirm this phenomenon, we examined the direct interactions between p53 and Bat3 by mixing bacterially purified His-Bat3 and GST-p53 with Flag antibody-purified HAUSP or its deletion mutants followed by GST pull-down assay in vitro ."
31647545
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal binds USP7 and TP53. 1 / 1
| 1
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"As shown in xref , ectopic expression of ABRO1 in HCT 116 p53 +/+ cells enhanced the interaction between USP7 and p53, whereas knockdown of ABRO1 weakened the interaction between USP7 and p53 in the presence of MG132 ( xref )."
25283148
TP53 binds USP7 and TRAF domain. 1 / 1
| 1
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"Both MDM2 and p53 bind USP7 on the TRAF domain, and co-crystal structures with peptides of both targets are available (PDB: 2FOJ , 2F1Y ; Fig. 2 a and b) [23,24] ."
28591556
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
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"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
HCT116 binds TP53, ABRAXAS2, and USP7. 1 / 1
| 1
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"To confirm this, we examined the endogenous interaction between ABRO1 and USP7 in HCT116 p53 +/+ cells and found that this interaction could be enhanced by DNA damage ( xref )."
25283148
USP7 activates TP53.
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USP7 activates TP53. 10 / 141
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"Consequently, USP7 has emerged as an attractive oncology target because its inhibition stabilizes p53, thereby promoting p53 dependent apoptosis in cancer cells."
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"Notably, USP7 can directly regulate not only the stability of p53, but also the protein stability of the MDM2 protein."
33421376
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"Here, we report that USP7 inhibitor, P22077, potently activates p53 by decreasing HDM2 levels in NB cells with an intact USP7-HDM2-p53 axis and efficiently inhibits tumor growth in vivo ."
24136231
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"Taken together, these findings indicate that TSPY1 can regulate the cell cycle and apoptosis by suppressing Usp7 mediated p53 function, promoting the proliferation of mouse spermatogonia."
29748603
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"Overexpression of USP7 induces p53 activation, leading to growth suppression and apoptosis."
23151129
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"Our finding that USP7 inhibition in vitro and in vivo significantly suppresses leukemic cell growth, alone and in combination with chemotherapy, independently of p53 status supports this notion."
32447346
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"Correspondingly, it is highly possible that the regulation of USP7 mediated p53 function by TSPY1 is an important molecular mechanism underlying its function in human spermatogenesis."
29748603
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"Notably, when simulating TSPY1 function in Tspy1 deficient spermatogonia cells derived from mouse testes, we observed the promotion of spermatogonial proliferation by TSPY1 along with signaling changes in the Usp7 mediated p53 pathway."
29748603
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"Inactivation of HAUSP in vivo modulates p53 function."
29056421
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"These findings strongly support the potential of TSPY1 function in the regulation of human spermatogonial proliferation by suppressing USP7 mediated p53 function."
29748603
USP7 activates mutated TP53. 1 / 1
| 1
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"These results demonstrate the critical roles of both USP7 and CHIP in regulating the cabozantinib-induced alteration of p53 stability.Targeting mutant p53 proteins through promoting their degradation is an attractive strategy for the development of anticancer drugs."
39793887
USP7 bound to WRAP53 activates TP53. 1 / 1
| 1
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR In this study, we report a new molecular process in which WDR79 interacts with USP7 to modulate the stability of Mdm2 and p53, which promotes the proliferation of NSCLC cells."
28406480
Modified USP7 activates TP53. 1 / 1
| 1
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"Collectively, the data suggest that overexpression of USP7 up-regulates steady-levels of Poleta independent of p53 and suggested that Poleta, like p53, could be a substrate of USP7."
25435364
USP7 deubiquitinates TP53.
1 1 | 135
USP7 deubiquitinates TP53. 10 / 133
1 1 | 131
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"Abraxas brother 1 (ABRO1), a component of the BRCC36-containing isopeptidase complex (BRISC), stabilises p53 by promoting its interaction with USP7 to reduce p53 ubiquitination (166)."
36969062
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"USP7 deubiquitinates Mdm2 and p53, and its overexpression causes Mdm2 and p53 stabilization."
26460617
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"Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."
29056421
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"It has been reported that the expression level of USP7 is elevated in several types of tumor cells.31 32 Overexpression of USP7 causes deubiquitination of HDM2 and degradation of P53, which can promote tumor progression."
40104064
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"HAUSP interacted with and deubiquitinated p53, leading to increased p53 levels."
15916963
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"Another example of de-ubiquitinizing enzyme is HAUSP (Herpesvirus associated ubiquitin specific protease), which antagonizes ubiquitination of p53 [XREF_BIBR]."
17488476
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"One of the most well-known substrate of USP7 is p53, and deubiquitination of p53 by USP7 is critical for its stabilization [XREF_BIBR], indicating its function in regulating tumor development."
29574466
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"Some well-established examples include histone deubiquitination by Ubp8 (24), p53 deubiquitination by both Usp7 and Usp10 (25, 26), free K48-linked ubiquitin-chain disassembly by Ubp14 (27), and removal of K63-linked ubiquitin chain from TRAF6 by A20 (28, 29)."
39798877
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"The observation that HAUSP can directly interact with and deubiquitylate both p53 and MDM2 creates a conundrum : how can HAUSP stabilize p53 while at the same time being able to stabilize MDM2, which is primarily responsible for the destruction of p53?"
16402859
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"USP7 deubiquitinates several tumour suppressors (p53, PTEN, FOXO and claspin) and E3 ligases (MDM2, Mule and viral proteins ICP0) and therefore regulates important signalling pathways that are involved in tumorigenesis XREF_BIBR XREF_BIBR."
25960197
USP7 deubiquitinates ubiquitinated TP53. 2 / 2
| 2
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"HAUSP specifically deubiquitinates the ubiquitinated p53 protein both in vitro and in vivo, and the expression of HAUSP was found to stabilize p53 in vivo and to promote p53 dependent cell growth arre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12507430
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"Single- or double ubiquitinated p53 are deubiquitinated by a protein called HAUSP XREF_BIBR."
25504419
Modified USP7 leads to the deubiquitination of TP53. 2 / 2
| 2
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"As shown in XREF_FIG, Mdm2 induced the ubiquitination of p53; however, p53 ubiquitination was significantly diminished by coexpression of USP10 or HAUSP."
20096447
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"There also seems to be a delicate balance between these proteins, as a modest reduction of HAUSP levels prevents p53 deubiquitination but complete ablation of HAUSP causes robust p53 stabilization."
20404858
USP7 inhibits TP53.
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USP7 inhibits TP53. 10 / 103
| 8 86
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"The inhibition of USP7 can reactivate p53 (90)."
34558642
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"USP7 directly regulates p53 stability or downregulates p53 by stabilizing MDM2."
35563444
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"Overexpression of USP7 and HDM2 inactivates P53 signaling in tumor cells and facilitates their progression, but suppression of these targets by conventional strategies to reactivate P53 function remains a challenge."
40104064
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"The inhibition of USP7 with HBX 41,108, a DUB to Hdm2 has shown to induce p53 dependent apoptosis with an IC in sub-micro-molar concentrations."
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"On the other hand, by ubiquitinating itself, MDM2 targets itself for destruction and promotes the p53 tumor suppressor pathway, a process that can be antagonized by the deubiquitinase herpesvirus associated ubiquitin specific protease (HAUSP)."
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"45 The aberrant activities of USP7 and HDM2 suppress the normal function of P53 and thereby disrupt the natural processes of apoptosis and cell-cycle progression in cells, which may contribute to cancer initiation."
40104064
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"Partial reductions in HAUSP levels lead to destabilization of p53, whereas more complete reductions may cause MDM2 destabilization and p53 accumulation."
32532965
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"In addition, USP7 is suppressed by various DUB inhibitors including HBX41108 and P22077, thereby regulating p53 [94-96]."
28801249
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"USP7 counteracts autoubiquitylation of MDM2 , thereby promoting p53 degradation ."
30974870
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"Inhibition of USP7 activated p53 via suppressing deubiquitination, which led to down-regulation of TfR1, accompanied by the decreased ferroptosis and myocardial I/R injury."
33157209
USP7 bound to TP53 inhibits TP53. 2 / 2
| 2
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"Alternatively, during lytic replication, USP7 in the K-RTA-OTUD4-USP7 complex is activated to enable efficient viral replication, while USP7 in the USP7-p53 complex might be specifically targeted by vIRF1 and vIRF3 to negate the antiviral effect of p53 signaling."
38215174
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"Furthermore, EBNA-1-USP7 interaction prevents the binding of USP7 to p53 and thereby diminishes p53 stabilization."
30807924
Modified USP7 inhibits TP53. 1 / 1
| 1
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"Expression of USP7, the target protein of EBNA1 and ICP0, however, effectively promotes increased levels of p53 by antagonizing proteasomal degradation of p53 through deubiquitination."
17291557
USP7 bound to exosomal EBNA1 inhibits TP53. 1 / 1
| 1
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"In addition, exosomal EBNA1 can interact with USP7 to prevent the down-regulation of p53 XREF_BIBR, XREF_BIBR."
29581754
USP7 bound to MDM2 inhibits TP53. 1 / 1
| 1
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"37 For instance, death domain associated protein (Daxx) promotes the binding of USP7 to Mdm2 and enhances Mdm2‐dependent p53 degradation."
37438558
USP7 decreases the amount of TP53.
| 47
USP7 decreases the amount of TP53. 10 / 48
| 46
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"The inhibition of USP7 stimulated transcription of p53-associated genes related to cell-cycle arrest and apoptosis."
34089649
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"Saridakis et al. have demonstrated that the USP7, a key regulator of p53, is strongly targeted by EBNA1 and consequently can lower p53 levels."
28729047
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"Similarly, in our study, we confirmed that knockdown of USP7 increases the p53 expression."
35948545
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"Conversely, USP7 overexpression is expected to decrease p53 expression, but does not affect p53 protein expression."
35948545
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"This suggests USP7 may negatively regulate p53 levels through MDM2."
25519684
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"Initially identified as a p53 DUB, it was later shown that, conversely, USP7 impairs p53 expression and function by regulating Mdm2 ubiquitylation [XREF_BIBR], and in so doing exerts pro oncogenic functions."
28473667
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"To further determine whether MLF2 suppresses p53 expression via USP7, we ectopically expressed p53 together with USP7 or both USP7 and MLF2 in Mdm2 p53 mouse embryonic fibroblast (MEF) cells."
37438558
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"USP7 inhibition in NB cells activated the p53 pathway via USP7 and MDM2 degradation, leading to reduced p53 ubiquitination and increased p53 expression in all sensitive NB cells."
37762082
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"On the other side, the ubiquitinated TP53 could be reversed and stabilized by USP7 and USP10, to keep the amount of TP53 in check."
31695837
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"Absence of HAUSP promoted the ubiquitinated form and thereby proteosomal degradation of MDM2, a negative regulator of p53 levels (14)."
30940656
USP7 decreases the amount of ubiquitinated TP53. 1 / 1
| 1
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"Conversely, FAM188B downregulation increased unbound USP7 and this free USP7 may decrease the level of ubiquitinated p53."
29795372
USP7 increases the amount of TP53.
| 35
USP7 increases the amount of TP53. 10 / 32
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"UNBS5162 actives USP7 and increases the p53 protein level."
39827292
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"However depletion of HAUSP in cells does not decrease p53 levels as predicted, but rather increases p53 levels, apparently due to HAUSP 's ability to bind and deubiquitinate Mdm2."
20096447
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"When USP7 was coexpressed with p53 in these cells, USP7 increased the expression levels of p53 as expected (Figure  4A)."
37438558
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"As shown in XREF_FIG, knockdown of USP7 reduced the levels of Mdm2 and p53, a result consistent with that of a previous study."
28406480
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"Inhibition of USP7 may inhibit the proliferation of gastric cancer cells by halting the cell cycle during the G2-M phase, maintaining p53 expression, and downregulating PD-L1 expression."
37396527
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"16 The discovery that USP7 modulates the levels of not only p53 but also Hdm2 and HdmX has greatly increased the complexity of its role within the p53–Hdm2 pathway."
20713061
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"USP7 Depletion Decreases Neuroblastoma Cell Growth, Increases Protein Expression of p53, and Decreases Protein Expression of EZH2."
37762082
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"Among the four sgRNAs _USP7, sg3_ USP7 most significantly increased the expression of p53 both in p53-mutated and p53-wild type LSCC cell lines in the results of qRT-PCR and western blot (Fig. 4A, B)."
35696794
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"USP7 enhances Tip60 acetyltransferase activity towards p53 at K120 and promotes p53-mediated pro-apoptotic gene expression [102]."
36497084
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"Almac4 treatment and USP7 depletion led to decreased USP7, MDM2, N-myc, and EZH2 expression levels and to increased p53 expression, with reduced p53 ubiquitination and increased EZH2 ubiquitination (Figure 9)."
37762082
Modified USP7 increases the amount of TP53. 2 / 2
| 2
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"In addition, USP7 overexpression significantly increased endogenous Mdm2 and p53 levels, but had no effect on STIP levels (XREF_SUPPLEMENTARY)."
26460617
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"Expression of USP7, the target protein of EBNA1 and ICP0, however, effectively promotes increased levels of p53 by antagonizing proteasomal degradation of p53 through deubiquitination."
17291557
USP7 increases the amount of mutated TP53. 1 / 1
| 1
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"Further studies indicated that USP7 knockdown could significantly decrease mutant p53 protein levels both in CRCs and CSC-enriched colorectal cancer cells."
39346740
USP7 ubiquitinates TP53.
| 13 2
USP7 ubiquitinates TP53. 10 / 16
| 13 2
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"The herpesvirus associated ubiquitin specific protease (HAUSP, also known as ubiquitin specific protease 7 (USP7)) can suppress cell growth by removing ubiquitin from polyubiquitinated p53 to prevent it from degradation (Li et al. 2002)."
16845885
reach
"It has been reported that the expression level of USP7 is elevated in several types of tumor cells.31 32 Overexpression of USP7 causes deubiquitination of HDM2 and degradation of P53, which can promote tumor progression."
40104064
reach
"On the other hand, knockdown of RORα further enhanced p53 ubiquitination, which was increased by the knockdown of HAUSP ( Figure 3 G)."
22152482
reach
"USP7 stabilizes MDM2 by deubiquitination, allowing MDM2 to ubiquitinate p53, leading to proteasomal degradation of p53."
37762082
reach
"According to previous findings, when it enters the nucleus, the GMPS-USP7 complex is formed with ubiquitin-specific protease 7 (USP7), which can promote the degradation of the p53 protein by deubiquitinating the negative p53 regulatory protein MDM2 [41,42]."
37484410
reach
"Moreover, we showed that CHIP knockdown abrogated the downregulation of p53 caused by USP7 knockdown (Fig. S5D), and simultaneous knockdown of CHIP and USP7 attenuated the enhanced ubiquitination of p53 in the cells subjected to USP7 knockdown (Fig. S5E)."
39793887
reach
"Fluorimetric quantification revealed that the USP7 and GMPS complex ubiquitylates p53 at a rate that is more than 20 times faster than USP7 alone (compare USP7 alone at 20 ' with USP7-GMPS at 1 ')."
15749019
reach
"First, ORF45 interacts with the p53 de-ubiquitinating enzyme USP7, which leads to increased p53 ubiquitination and degradation [43]."
36146816
reach
"Moderate down regulation of HAUSP reduces the deubiquitination of p53, leading to p53 destabilization and therefore favors cell proliferation [XREF_BIBR]."
20932800
reach
"We further determined whether ABRO1 facilitates p53 deubiquitination in a USP7 dependent manner; as shown in XREF_FIG, knockdown of USP7 impaired ABRO1 mediated p53 stability and deubiquitination."
25283148
USP7 acetylates TP53.
| 1
USP7 acetylates TP53 on K120. 1 / 1
| 1
sparser
"USP7 also increases Tip60-dependent p53-K120 acetylation, which is required for its induction of the pro-apoptotic gene, PUMA [ xref ]."
25545885
TP53 affects USP7
54 2 | 1 179 244
TP53 binds USP7.
54 2 | 1 133 242
TP53 binds USP7. 10 / 363
54 2 | 1 116 169
sparser
"RORα promotes interactions between p53 and USP7 but does not affect interactions between p53 and MDM2 (ref. xref )."
25283148
reach
"HAUSP interacted with and deubiquitinated p53, leading to increased p53 levels."
15916963
reach
"It has been reported that the EBNA1 protein binds to USP7 with high affinity and impairs the interaction of p53 and USP7."
36624687
reach
"The interaction between p53 and USP7 can be disrupted by EBNA1."
33505922
reach
"USP7 binds to and directly deubiquitinates p53 and inhibits its degradation."
36624687
sparser
"Interest in USP7 was renewed by the observation that USP7 binds to the C-terminal domain of p53, promotes its de-ubiquitination and subsequent stabilization [24] ."
17961905
sparser
"USP7 was also shown to be involved in the stress-induced p53 translocation to the mitochondria since a stress-inducible USP7-p53 complex was formed at the mitochondria resulting in p53 de-ubiquitinati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961905
sparser
"It has been reported that the EBNA1 protein binds to USP7 with high affinity and impairs the interaction of p53 and USP7."
36624687
sparser
"USP7 binds to and directly deubiquitinates p53 and inhibits its degradation."
36624687
sparser
"32 In response to DNA damage, HAUSP interacts with p53, causing its stabilization."
25843733
USP7 binds TP53 and MDM2. 10 / 50
| 14 36
sparser
"In a similar experiment, alanine substitutions of NTD residues known to be important for interactions of USP7 substrates such as p53 and MDM2 ( xref , xref ) led to loss of (W 149 A and DWGFS 152 A 5 ) or greatly diminished (R 88 A) interaction of the residue 1 to 220 USP7 fragment with vIRF-2 (data not shown), indicating canonical interaction of the vIRF-2 PSTS motif with the USP7 TRAF-like domain despite the additional requirements for vIRF-2 and its binding region (residues 241 to 260) to interact with USP7."
31666375
sparser
"For example, USP7 (HAUSP) interacts with MDM2 to regulate the turnover of p53 together, and it is also able to increase the stability of MDM2 xref ."
24714733
sparser
"The Protein Data Bank () accession numbers for the atomic coordinates of the HAUSP TRAF-like domain alone, the HAUSP TRAF-like domain bound to p53 and MDM2 peptides, and HAUSP (residues 53–560) are 2F1W, 2F1X, 2F1Y, and 2F1Z, respectively."
16402859
sparser
"We show that the N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2, falling between p53 residues 359-367 and MDM2 residues 147-159."
16474402
sparser
"Moreover, p53 was found to be upregulated in MDM2 −/− p53 −/− double-deficient MEFs after co-transfection of both p53 and ABRO1, indicating that ABRO1-dependent p53 stabilization is made possible by enhanced p53-USP7 interaction without effects on p53-MDM2 interaction and MDM2 stability."
25283148
sparser
"The accumulated evidence regarding the interactions of USP7 and MDM2 with p53 indicates that these interactions are important in regulating the stability of p53 under both physiological and pathological conditions."
25283148
sparser
"Structural studies have shown that p53 and MDM2 interact with the N-terminus of USP7 in a mutually exclusive manner [ xref ]."
23151129
sparser
"Taken together, the activation of USP7-MDM2-p53 interaction can promote the occurrence and development of tumors."
31114498
reach
"19 The identification of Nucleolin as a substrate of HAUSP and a member of the HAUSP, p53, and MDM2 complex has added to the complexity of its dynamics, implicating cellular adaptations to combat DNA damage stress by upregulating Nucleolin in the presence of ionizing radiation."
29967688
sparser
"The N-terminal domain of USP7 binds two closely spaced 4-residue sites in both p53 and MDM2 (p53 residues 359−367 and MDM2 residues 147−159) ( xref )."
19489724
BAG6 binds USP7 and TP53. 3 / 3
| 3
sparser
"Immunoprecipitation of protein extracts with anti-p53 antibody and subsequent immunoblot analysis revealed a trimeric protein interaction between p53, Bat3 and HAUSP as both HA-Bat3 and Flag-HAUSP were detected in the p53-immunoprecipitated complex ( xref )."
31647545
sparser
"These results suggest that the formation of p53–HAUSP–Bat3 complex may prevent p53 from being recognized and binding to its proteasome receptor S5a, subsequently leading to the accumulation and stabilization of p53 in nucleus ( xref ) though we still do not know whether there is conformational change in Bat3 and p53 at present."
31647545
sparser
"Notably, we revealed that a p53–HAUSP–Bat3 trimeric protein complex could exist in vivo with HAUSP serving as a binding mediator for enhanced interaction between p53 and Bat3, which antagonizes the interaction of p53 with its proteasome receptor S5a and promotes the accumulation of p53 in the nucleus."
31647545
USP7 binds TP53 and EBNA1. 3 / 3
| 3
sparser
"The results of these experiments demonstrated that the deletion of Ubl2 did not inhibit the interaction of USP7 with p53 or EBNA1 ( xref , A and B )."
32587091
sparser
"NMR studies of USP7 bound by EBNA1 and p53 indicated that p53 and EBNA bind the same pocket but p53 but makes less extensive contacts with USP7."
19489724
sparser
"Crystal structure analysis showed that USP7 binds to its substrate p53 and its inhibitory interactor Epstein–Barr nuclear antigen 1 (EBNA1) protein through the same pocket but the former binding partner p53 exhibit weaker contacts with USP7 [ xref , xref ]."
28031783
TP53 binds USP7 and USP10. 2 / 2
| 2
sparser
"For example, USP7 and USP10 bind to and deubiquitylate their substrate p53 to mediate its role for suppression of cell propagation upon cellular stresses by counteracting its degradation xref – xref ."
31745110
sparser
"Using a quantitative mass spectrometry approach and focusing on ubiquitin ligases and proteases, we were able to determine that the interaction between p53 and two DUBs, USP7 and USP10, was reduced under DMOG treatment ( xref A)."
30067985
GMPS binds USP7 and TP53. 2 / 2
| 2
sparser
"Considering that the interaction among GMPS, USP7 with p53 is required for the deubiquitination and stabilization of p53 [ xref , xref ]. we next determined the interaction of GMPS and USP7 with p53 in the p53wt breast cancer cell lines MCF-7 and DU4475 by co-IP assays."
33742136
sparser
"In the context of X-ray radiation, GMPS bound both USP7 and TP53 (Fig. xref b), and TP53 protein levels were elevated upon GMPS overexpression (Additional file xref : Figure S1e), suggesting that GMPS promotes TP53 protein stability."
32005234
MDM2 binds TP53, WRAP53, and USP7. 2 / 2
| 2
sparser
"Taken together, our findings reveal a novel role of WDR79 in the proliferation of NSCLC cells and could pinpoint a new mechanism by which WDR79 and USP7 functionally interact to modulate the Mdm2-p53 pathway."
28406480
sparser
"In this study, we report a new molecular process in which WDR79 interacts with USP7 to modulate the stability of Mdm2 and p53, which promotes the proliferation of NSCLC cells."
28406480
USP7 binds TRAF and TP53. 2 / 2
| 2
sparser
"As shown in xref , p53 has 393 amino acid residues that can be subdivided into five domains: the N-terminal transactivation domains (TAD) that are responsible for its binding to the p53-binding sites on MDM2 and MDMX, a proline-rich region (PP) that contains five PxxP motifs and is essential for inducing apoptosis, a DNA-binding domain (DBD), a tetramerization domain (TET), and a C-terminal domain (CTD) that is critical for the binding of p53 to the TRAF domain of USP7 ( xref ; xref )."
32300595
sparser
"On one hand, p53 binds to TRAF domain and C-terminal (amino acids 880–1050) of USP7, and then USP7 ubiquitinates p53 directly and prevents it from degradation."
31114498
DAXX binds USP7, MDM2, and TP53. 2 / 2
| 1 1
sparser
"Although the molecular mechanism for the interactions of DAXX, HAUSP, Mdm2, and p53 underlying this regulatory pathway are largely unknown, an important clue is provided by our observation that, at le[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21134643
reach
"The most significant binding partners identified to interact with the C1 domain are the TNF-R1 and TRAIL-R1 -- Modulator of Apoptosis-1 (MOAP-1) complexes and the MDM2, DAXX, HAUSP, and p53 complex [XREF_BIBR, XREF_BIBR] (XREF_FIG)."
22577550
ELP2 binds MDM2, TP53, and USP7. 2 / 2
| 2
sparser
"Considering that the effect of STIP on Mdm2 or p53 was independent of each other, we hypothesize that STIP may associate with the USP7-Mdm2 or USP7-p53 complexes."
26460617
sparser
"These data indicated that STIP may simultaneously bind to USP7 and either Mdm2 or p53, mediating the assembly of ternary STIP-USP7-Mdm2 and STIP-USP7-p53 complexes, respectively."
26460617
USP7 binds NCL, TP53, and MDM2. 2 / 2
| 2
sparser
"We next verified that HAUSP and nucleolin could form a complex with p53 and Mdm2 by examining the interaction between HAUSP and nucleolin in p53- and Mdm2-depleted cells."
26238070
sparser
"Moreover, p53 also could not interact with HAUSP and nucleolin in Mdm2-depleted cells ( xref )."
26238070
ABRAXAS2 binds USP7 and TP53. 2 / 2
| 2
sparser
"Based on the results showing association of ABRO1, p53 and USP7, we presumed that ABRO1 might promote interaction between USP7 and p53, and regulate USP7-dependent deubiquitination of p53."
25283148
sparser
"ABRO1 forms a complex with USP7 and p53."
25283148
TP53 binds USP7 and NCL. 1 / 1
| 1
sparser
"We hypothesized that Mdm2 acts as a mediator between HAUSP and nucleolin in the normal state, and that p53 may be associated with the HAUSP and nucleolin interaction in the DNA damaged condition."
26238070
TP53 binds MDM4 and USP7. 1 / 1
| 1
sparser
"It has also been reported that some SNPs of p53, Mdm2(Murine double minute 2), MdmX and Hausp (Herpes virus-associated ubiquitin-specific protease) in p53 pathway are associated with the risk of the women's reproduction disorder."
22917899
USP7 binds MDM4, MDM2, and TP53. 1 / 1
| 1
sparser
"Further insight into the mechanism by which ATM switches the interactions between HAUSP, Mdmx, Mdm2 and p53, to favor p53 activation may offer new tools for therapeutic intervention in the p53 pathway for cancer treatment."
16082221
TP53 binds USP4, USP7, USP10, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
TP53 binds DAXX and USP7. 1 / 1
| 1
sparser
"MDM2 is a negative regulator of p53 that interacts with DAXX and HAUSP to form tertiary complex (MDM2-DAXX-HAUSP) [ xref ]."
30237857
USP7 binds Ubiquitin, MDM2, and TP53. 1 / 1
| 1
sparser
"USP7 can bind Mdm2 or p53 via its N-terminal and C-terminal regions in a mutually exclusive manner, which consequently stabilizes the two proteins by removing ubiquitin."
28406480
Ubiquitin binds USP7, TRAF, MDM2, and TP53. 1 / 1
| 1
sparser
"The deubiquitinase USP7 binds Mdm2 or p53 via its N -terminal TRAF-domain or C-terminal region in a mutually exclusive manner to remove ubiquitins and stabilize the two proteins [ xref – xref ]."
26460617
USP7 binds TP53 and AKT. 1 / 1
| 1
sparser
"Although the essential role of USPs in protein degradation is well established, less is known about the function and regulation of specific family members: for example Usp7 has been associated with p53 and Akt turnover, Usp8 with receptor tyrosine endocytosis, Usp33 with the Von Hippel–Lindau disease (VHL) pathway and Usp19 is thought to have a role in muscle development [ xref ]."
25886905
TP53 binds DAXX, EBNA1, and USP7. 1 / 1
| 1
sparser
"We identify the ubiquitin-like (Ubl) domain 2 of USP7 as critical for the interaction and deubiquitination of p65 but dispensable for the interaction of USP7 with the USP7 substrates p53, DAXX, and EBNA1."
32587091
USP7 binds MDM2, TP53, and CDKN1A. 1 / 1
| 1
sparser
"In addition to the altered levels of HDM2, p53 and p21 associated with its use, P22077 treatment also caused reduced levels of DNA damage proteins DDB1, RBX1, DCAF7 and DCAF11, all of which are subunits of E3 ligases, indicating a previously unknown functional link between USP7 and enzymes involved in DNA repair [ xref ]."
23822887
USP7 binds ubiquitinated TP53. 1 / 1
| 1
reach
"USP7 also interacts with the polyubiquitinated p53 and promotes p53 deubiquitination and stability."
20531303
TP53 binds GST, MDM2, NCL, and USP7. 1 / 1
| 1
sparser
"As expected, purified GST-p53 protein could bind Mdm2, nucleolin, and HAUSP ( xref , upper panel)."
26238070
TP53 binds USP7 and FOXO4. 1 / 1
| 1
sparser
"The results of the interaction between the USP7 and FOXO4 in H1299 human lung carcinoma cells that lack p53 suggested that the interaction is p53 independent. xref , xref However, p53 and FOXOs have noticeable similarities such as the ability to stimulate cell-cycle arrest and cell death and they are both regulated by USP7. xref "
35005106
USP7 binds TP53 and GST. 1 / 1
| 1
sparser
"To confirm this phenomenon, we examined the direct interactions between p53 and Bat3 by mixing bacterially purified His-Bat3 and GST-p53 with Flag antibody-purified HAUSP or its deletion mutants followed by GST pull-down assay in vitro ."
31647545
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal binds USP7 and TP53. 1 / 1
| 1
sparser
"As shown in xref , ectopic expression of ABRO1 in HCT 116 p53 +/+ cells enhanced the interaction between USP7 and p53, whereas knockdown of ABRO1 weakened the interaction between USP7 and p53 in the presence of MG132 ( xref )."
25283148
TP53 binds USP7 and TRAF domain. 1 / 1
| 1
reach
"Both MDM2 and p53 bind USP7 on the TRAF domain, and co-crystal structures with peptides of both targets are available (PDB: 2FOJ , 2F1Y ; Fig. 2 a and b) [23,24] ."
28591556
USP7 binds USP10, USP42, and TP53. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
HCT116 binds TP53, ABRAXAS2, and USP7. 1 / 1
| 1
sparser
"To confirm this, we examined the endogenous interaction between ABRO1 and USP7 in HCT116 p53 +/+ cells and found that this interaction could be enhanced by DNA damage ( xref )."
25283148
TP53 activates USP7.
| 25
TP53 activates USP7. 10 / 23
| 23
reach
"Upregulated USP7 further stabilizes MDM2 protein, which further downregulates p53 protein level."
37829803
reach
"24 The absence of p53 increases cell proliferation in vivo and accelerates atherosclerosis.26 Besides, it is proved that p53 deficiency enhances the LPS-induced ALI in vivo.25 Caveolin-1 is identified a novel transduction factor and involved in the progression of pulmonary emphysema by activating ATM-p53-p21 pathway.28 Moreover, in COPD patients, p53/p21 pathway can be activated by up-regulating USP7 to mediate cell premature senescence."
38022822
reach
"Although deletion of p53 did not completely rescue the embryonic lethality of the hausp knockout, embryonic development was extended in both hausp and p53 double knockout embryos."
19946331
reach
"P53 mediated the regulation of USP7 on the radiosensitivity of LSCC cell line."
35696794
reach
"To determine whether there was increased apoptosis due to p53 activation in hausp knockout embryos, a TUNEL (TdT mediated dUTP Nick-End Labeling) assay was performed on wild-type and hausp knockout embryos of both days E6.5 (XREF_FIG) and E7.5 (XREF_FIG)."
19946331
reach
"To explore how did p53 mediate the regulation of USP7 on the radiosensitivity of LSCC cell line, flow cytometric analysis was performed."
35696794
reach
"Hausp knockout was partially rescued by p53 knockout."
19946331
reach
"The results showed that knockout of p53 did not rescue the lethality of the hausp knockout."
19946331
reach
"Owing to the observation of p53 activation in hausp knockout embryos, we attempted to rescue the lethality of hausp knockout mice by generating hausp and p53 double knockout mice."
19946331
reach
"The concurrent loss of TP53 effectively rescued the cytotoxic effect of USP7 knockout, as also observed for PPM1D knockout (XREF_FIG)."
30045945
TP53 bound to SGTA activates USP7. 1 / 1
| 1
reach
"In a well studied example, the N-terminal domain of the human UBP called herpesvirus associated ubiquitin specific protease ([HAUSP] USP7) binds the p53 tumor suppressor, allowing HAUSP to cleave polyubiquitin-p53 conjugates and, thereby, limit p53 degradation."
17145966
TP53 bound to USP7 activates USP7. 1 / 1
| 1
reach
"Conflicting studies show that binding of p53 to USP7 either promotes the deubiquitination and subsequent stabilization of p53 [XREF_BIBR, XREF_BIBR] or that disruption of USP7 stabilizes p53 [XREF_BIBR, XREF_BIBR]."
20210752
TP53 inhibits USP7.
| 14
TP53 inhibits USP7. 10 / 13
| 12
reach
"P53 levels were increased by compound 4 in all three cell lines, confirming its inhibition of USP7."
30367141
reach
"To determine whether p53 mediates USP7 inhibition‐induced SnC apoptosis by upregulating pro‐apoptotic genes, we compared BBC3, PMAIP1, and FAS mRNA levels in non‐SnCs and IR‐induced SnCs with or without P5091 treatment."
32064756
reach
"The colony formation assay results demonstrated that overexpression of p53 reversed the effects of USP7 on p53-mutated or p53-wild type LSCC cell line (Fig. 4C, D)."
35696794
reach
"These results suggest that p53 mediates USP7 deletion-induced apoptosis in a cell-autonomous manner.The finding of neuronal apoptosis also led us to ask whether this cellular phenotype might translate to a reduction in brain volume."
39862434
reach
"Ras association domain-containing protein RASSF1A is a potential tumour suppressor that disrupts the association of USP7 to MDM2, allowing the latter to self-ubiquitinate and stabilising p53 [54] ."
28591556
reach
"Previous research indicated that the small molecule HBX 41108 modulates p53 expression by blocking USP7’s de-ubiquitination activity, thereby inhibiting cancer cell growth [34]."
40006058
reach
"Concomitant deletion of p53 partially rescued the developmental defects in hausp nes-cre conditional knockout mice, providing direct evidences for p53 dependent functions of HAUSP."
21350561
reach
"XREF_BIBR, XREF_BIBR The p53 staining was weak but was detectable in some of the cells in hausp FL/FL; nes-cre cortex at day E12.5 (data not shown), indicating the onset of the accumulation of p53 following depletion of HAUSP protein."
21350561
reach
"As shown in XREF_FIG, both p53 and Mdm2 had decreased half-lives in hausp heterozygote MEF cells (lanes 5-8) compared with that in wild-type MEF cells (lanes 1-4)."
19946331
reach
"However, whether any of these mechanisms contribute to USP7 inhibition‐induced SnC apoptosis has yet to be determined.The results from our studies also suggest that p53 may mediate USP7 inhibition‐induced SnC apoptosis via both transcriptional and post‐transcriptional mechanisms."
32064756
TP53 bound to TSPYL5 inhibits USP7. 1 / 1
| 1
reach
"In HEK293 cells, we observed that TSPYL5 could competitively bind to the N-terminal domain of deubiquitylase USP7 in conjunction with p53 and reduce the protective effects of USP7 on p53, resulting in ubiquitin mediated degradation of p53, and that the co-transfection of TSPY1 and TSPYL5 enhanced this effect."
29748603
TP53 inhibits mutated USP7. 1 / 1
| 1
reach
"Although loss of Trp53, the gene encoding p53 in mice, rescues brain size in Usp7 mutant mice, co-deletion of p53 fails to improve newborn survival, suggesting that USP7 plays essential roles in the nervous system through unknown p53-independent mechanisms."
39862434
TP53 ubiquitinates USP7.
| 1 2
TP53 ubiquitinates USP7. 2 / 2
| 2
sparser
"At the same time ubiquitination CHIP β-TrCP1 E3 Topors CARP-1 Synoviolin CARP-2 ARF-BP1 E4 Cul4A p300 PirH2 COP1 Mdm2 E6 E6AP E2 UbcH5c UbcH5b Deubiquitination Ub p53 HAUSP E3 MSL-2 E4F1 WWP1 E2 Ubc13 Ubiquitination Ub p53 p53 p53 p53 Degradation Stabilization Modulation of p53 functin Figure 3.  Ubiquitin-ligases that control p53 function and activity."
19929178
sparser
"We observed that USP7 efficiently attenuated CHIP-mediated p53 Y220C K48-linked ubiquitination ( xref , F and G )."
39793887
Ubiquitinated TP53 leads to the ubiquitination of USP7. 1 / 1
| 1
reach
"Ubiquitination of p53 is downregulated by deubiquitinating enzymes USP7, USP10 and USP11 [ 35–37 ]."
30763716
TP53 decreases the amount of USP7.
| 3
TP53 decreases the amount of USP7. 3 / 3
| 3
reach
"Under insufficient glucose availability, the level of USP7 is inhibited by p53, resulting in degradation of PRMT1 via ubiquitination of the proteasome pathway, thereby inhibiting the Warburg effect and proliferation of NSCLC cells."
39009589
reach
"However, activation of p53 mediates protein degradation of PRMT1 through inhibiting the level of USP7 under glucose insufficiency."
39009589
reach
"Additionally, the expressions of p53 and p21 could be promoted by the overexpression of USP7, which was reversed by the downregulation of p53 ( Figure 4G,H)."
35538032
TP53 deubiquitinates USP7.
| 2
TP53 deubiquitinates USP7. 2 / 2
| 2
reach
"Knockdown of the p53 deubiquitinating enzyme USP7 and HAUSP also reverses the supervillin phenotype, blocking the increase in p53 levels seen after supervillin knockdown and accentuating the decrease in p53 levels triggered by supervillin overexpression."
23382381
reach
"It stabilizes p53 and induces p53-dependent apoptosis in cancer cells through inhibition of the p53-deubiquitinating enzyme USP7 [92]."
| PMC
TP53 increases the amount of USP7.
| 1
TP53 increases the amount of USP7. 1 / 1
| 1
reach
"Their results indicated that p53 loss did not completely rescue the loss of HAUSP, leaving open a role for PTEN in HAUSP-cKO mice."
24860420
EBNA1 affects MCMBP, MDM2, MDM4, TP53, UBE2E1, USP7, vIRF-1, and vIRF-4
| 1
USP7 binds TP53, MDM2, MDM4, MCMBP, UBE2E1, vIRF-1, vIRF-4, and EBNA1. 1 / 1
| 1
sparser
"USP7 can interact with p53, HDM2, HDMX, MCM-BP, UbE2E1, vIRF1, vIRF4, and EBNA1 through the TRAF-like domain [ xref , xref , xref , xref , xref , xref , xref ]."
33498168
EBNA1 affects DAXX
| 1
TP53 binds DAXX, EBNA1, and USP7. 1 / 1
| 1
sparser
"We identify the ubiquitin-like (Ubl) domain 2 of USP7 as critical for the interaction and deubiquitination of p65 but dispensable for the interaction of USP7 with the USP7 substrates p53, DAXX, and EBNA1."
32587091
DAXX affects TP53, and USP7
| 1
TP53 binds DAXX and USP7. 1 / 1
| 1
sparser
"MDM2 is a negative regulator of p53 that interacts with DAXX and HAUSP to form tertiary complex (MDM2-DAXX-HAUSP) [ xref ]."
30237857
DAXX affects EBNA1, TP53, and USP7
| 1
TP53 binds DAXX, EBNA1, and USP7. 1 / 1
| 1
sparser
"We identify the ubiquitin-like (Ubl) domain 2 of USP7 as critical for the interaction and deubiquitination of p65 but dispensable for the interaction of USP7 with the USP7 substrates p53, DAXX, and EBNA1."
32587091
CDKN1A affects USP7
| 1
USP7 binds MDM2, TP53, and CDKN1A. 1 / 1
| 1
sparser
"In addition to the altered levels of HDM2, p53 and p21 associated with its use, P22077 treatment also caused reduced levels of DNA damage proteins DDB1, RBX1, DCAF7 and DCAF11, all of which are subunits of E3 ligases, indicating a previously unknown functional link between USP7 and enzymes involved in DNA repair [ xref ]."
23822887
ATRX affects MDM2, RASSF5, TP53, TP63, TP73, and USP7
| 1
ATRX binds RASSF5, MDM2, USP7, TP53, TP63, and TP73. 1 / 1
| 1
sparser
"The DAXX helical bundle (DHB) domain has been reported to interact with ATRX, RASSF1C, MDM2, HAUSP, P53, P63, and P73 (Escobar-Cabrera et al., xref ; Gostissa et al., xref ; Tang et al., xref ; Tang et al., xref )."
28875424
AKT affects USP7
| 1
USP7 binds TP53 and AKT. 1 / 1
| 1
sparser
"Although the essential role of USPs in protein degradation is well established, less is known about the function and regulation of specific family members: for example Usp7 has been associated with p53 and Akt turnover, Usp8 with receptor tyrosine endocytosis, Usp33 with the Von Hippel–Lindau disease (VHL) pathway and Usp19 is thought to have a role in muscle development [ xref ]."
25886905
ABRAXAS2 affects HCT116, TP53, and USP7
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HCT116 binds TP53, ABRAXAS2, and USP7. 1 / 1
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"To confirm this, we examined the endogenous interaction between ABRO1 and USP7 in HCT116 p53 +/+ cells and found that this interaction could be enhanced by DNA damage ( xref )."
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