IndraLab

Statements

TP53 inhibits USP7. 12 / 13
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"P53 levels were increased by compound 4 in all three cell lines, confirming its inhibition of USP7."
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"To determine whether p53 mediates USP7 inhibition‐induced SnC apoptosis by upregulating pro‐apoptotic genes, we compared BBC3, PMAIP1, and FAS mRNA levels in non‐SnCs and IR‐induced SnCs with or without P5091 treatment."
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"The colony formation assay results demonstrated that overexpression of p53 reversed the effects of USP7 on p53-mutated or p53-wild type LSCC cell line (Fig. 4C, D)."
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"These results suggest that p53 mediates USP7 deletion-induced apoptosis in a cell-autonomous manner.The finding of neuronal apoptosis also led us to ask whether this cellular phenotype might translate to a reduction in brain volume."
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"Ras association domain-containing protein RASSF1A is a potential tumour suppressor that disrupts the association of USP7 to MDM2, allowing the latter to self-ubiquitinate and stabilising p53 [54] ."
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"Previous research indicated that the small molecule HBX 41108 modulates p53 expression by blocking USP7’s de-ubiquitination activity, thereby inhibiting cancer cell growth [34]."
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"Concomitant deletion of p53 partially rescued the developmental defects in hausp nes-cre conditional knockout mice, providing direct evidences for p53 dependent functions of HAUSP."
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"XREF_BIBR, XREF_BIBR The p53 staining was weak but was detectable in some of the cells in hausp FL/FL; nes-cre cortex at day E12.5 (data not shown), indicating the onset of the accumulation of p53 following depletion of HAUSP protein."
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"As shown in XREF_FIG, both p53 and Mdm2 had decreased half-lives in hausp heterozygote MEF cells (lanes 5-8) compared with that in wild-type MEF cells (lanes 1-4)."
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"However, whether any of these mechanisms contribute to USP7 inhibition‐induced SnC apoptosis has yet to be determined.The results from our studies also suggest that p53 may mediate USP7 inhibition‐induced SnC apoptosis via both transcriptional and post‐transcriptional mechanisms."
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"Like RNAi mediated USP7 silencing in cancer cells, HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene, and inhibited cancer cell growth (Colland et al., 2009)."
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"These results suggested that although deletion of p53 failed to rescue the neonatal lethality of hausp FL/FL; nes-cre mice, survival of neural cells and brain development were largely restored in the absence of p53."
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