IndraLab

Statements

TP53 binds USP7 and BAG6. 3 / 3
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"Notably, we revealed that a p53–HAUSP–Bat3 trimeric protein complex could exist in vivo with HAUSP serving as a binding mediator for enhanced interaction between p53 and Bat3, which antagonizes the interaction of p53 with its proteasome receptor S5a and promotes the accumulation of p53 in the nucleus."
31647545
sparser
"These results suggest that the formation of p53–HAUSP–Bat3 complex may prevent p53 from being recognized and binding to its proteasome receptor S5a, subsequently leading to the accumulation and stabilization of p53 in nucleus ( xref ) though we still do not know whether there is conformational change in Bat3 and p53 at present."
31647545
sparser
"Immunoprecipitation of protein extracts with anti-p53 antibody and subsequent immunoblot analysis revealed a trimeric protein interaction between p53, Bat3 and HAUSP as both HA-Bat3 and Flag-HAUSP were detected in the p53-immunoprecipitated complex ( xref )."
31647545