The INDRA Database

reach

"We have previously reported that the ubiquitin-specific peptidase 7 (USP7) may be a novel target for senolysis as inhibition of USP7 can selectively induce apoptosis of SnCs by increasing the level of p53 (He et al., 2020a) ."

35252191

➶

reach

"On the other side, the ubiquitinated TP53 could be reversed and stabilized by USP7 and USP10, to keep the amount of TP53 in check."

31695837

➶

reach

"USP7 (ubiquitin specific protease 7), which deubiquitinates HDM2, can lead to increased levels of HDM2 and decreased levels of p53."

22649774

➶

reach

"Moreover, these changes correlated with the levels of p53, indicating that USP7 inhibition can partially restore the expression of p53 and its downstream pro‐apoptotic proteins in SnCs."

32064756

➶

reach

"However, p53 levels in P5091‐treated WI‐38 SnCs remained slightly lower than the basal level of p53 in untreated non‐SnCs, suggesting that USP7 inhibition only partially restored the basal levels of p53 in WI‐38 SnCs and did not dramatically increase p53 expression as seen in WI‐38 cells after exposure to IR (Figure 1a, c)."

32064756

➶

reach

"Although a partial reduction in HAUSP can increase p53 levels, drastic reduction can have the opposite effect [17]."

15865937

➶

reach

"However depletion of HAUSP in cells does not decrease p53 levels as predicted, but rather increases p53 levels, apparently due to HAUSP 's ability to bind and deubiquitinate Mdm2."

20096447

➶

reach

"There is precedent for this possibility as, under some circumstances, USP7 can negatively regulate p53 levels by stabilizing the Mdm2 E3 ligase XREF_BIBR, XREF_BIBR."

21305000

➶

reach

"Inhibition of USP7 is expected to increase p53 levels, leading to anti-tumour activity [79], [80]."

26852935

➶

reach

"These findings are in agreement with our suggestion that USP7 inhibition upregulates p53 expression at least in part via promoting MDM2 proteasome degradation."

32064756

➶

reach

"USP7/HAUSP can elongate p53; however, depletion of USP7/HAUSP also induces upregulation of p53 protein expression [27]."

| PMC

➶

reach

"Similar to RNAi-mediated USP7 silencing in cancer cells, HBX41,108 treatments stabilized p53, activated transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth [119] ."

24239534

➶

reach

"Initially identified as a p53 DUB, it was later shown that, conversely, USP7 impairs p53 expression and function by regulating Mdm2 ubiquitylation [XREF_BIBR], and in so doing exerts pro oncogenic functions."

28473667

➶

reach

"This suggests USP7 may negatively regulate p53 levels through MDM2."

25519684

➶

reach

"However, depletion of HAUSP did not decrease cellular p53 levels, as predicted, but instead led to an increase in p53 levels."

28233861

➶

reach

"The mechanism by which USP7 inhibition increases p53 expression is likely attributable in part to the reduction of MDM2 expression as USP7 stabilizes MDM2 via deubiquitinating MDM2 (Li et al., 2004)."

32064756

➶

reach

"The stabilized USP7/HAUSP can enhance Mdm2 and decrease p53 protein expression."

| PMC

➶

reach

"HCT116 USP7 -/- cells grow extremely slowly because USP7 knockout leads to constitutively high level of p53 and p21."

25435364

➶

reach

"Absence of HAUSP promoted the ubiquitinated form and thereby proteosomal degradation of MDM2, a negative regulator of p53 levels (14)."

30940656

➶

reach

"Thus, HAUSP-mediated de-ubiquitination can bring about increased levels of MDM2 that then accelerate p53 degradation to directly reduce the level of p53."

32532965

➶

reach

"However, double silencing of USP7 and FAM188B restored the p53 level."

29795372

➶

reach

"Knockdown of USP7 expression increases p53 expression and inhibits colon cancer cells proliferation (Colland et al., 2009)."

34812471

➶

reach

"It’s widely believed that USP7 impairs p53 level via MDM2, but meanwhile, USP7 can remove ubiquitin off P53 in a direct manner."