IndraLab

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TP53 bound to SGTA activates USP7. 1 / 1
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"In a well studied example, the N-terminal domain of the human UBP called herpesvirus associated ubiquitin specific protease ([HAUSP] USP7) binds the p53 tumor suppressor, allowing HAUSP to cleave polyubiquitin-p53 conjugates and, thereby, limit p53 degradation."