IndraLab

Statements

USP7 ubiquitinates TP53. 6 / 7
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"Moderate down regulation of HAUSP reduces the deubiquitination of p53, leading to p53 destabilization and therefore favors cell proliferation [XREF_BIBR]."
20932800
reach
"Different strategies are being employed to achieve this, including Ube1 inhibition to prevent Ub activation, HDM2 inhibition to block p53 polyubiquitination, and USP7 and HAUSP inhibition to promote HDM2 degradation."
23822887
sparser
"Fluorimetric quantification revealed that the USP7-GMPS complex ubiquitylates p53 at a rate that is more than 20 times faster than USP7 alone (compare USP7 alone at 20′ with USP7-GMPS at 1′)."
15749019
sparser
"On one hand, p53 binds to TRAF domain and C-terminal (amino acids 880–1050) of USP7, and then USP7 ubiquitinates p53 directly and prevents it from degradation."
31114498
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"Fluorimetric quantification revealed that the USP7 and GMPS complex ubiquitylates p53 at a rate that is more than 20 times faster than USP7 alone (compare USP7 alone at 20 ' with USP7-GMPS at 1 ')."
15749019
reach
"We further determined whether ABRO1 facilitates p53 deubiquitination in a USP7 dependent manner; as shown in XREF_FIG, knockdown of USP7 impaired ABRO1 mediated p53 stability and deubiquitination."
25283148