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USP7 ubiquitinates TP53. 16 / 17
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"Fluorimetric quantification revealed that the USP7-GMPS complex ubiquitylates p53 at a rate that is more than 20 times faster than USP7 alone (compare USP7 alone at 20′ with USP7-GMPS at 1′)."
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"The herpesvirus associated ubiquitin specific protease (HAUSP, also known as ubiquitin specific protease 7 (USP7)) can suppress cell growth by removing ubiquitin from polyubiquitinated p53 to prevent it from degradation (Li et al. 2002)."
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"It has been reported that the expression level of USP7 is elevated in several types of tumor cells.31 32 Overexpression of USP7 causes deubiquitination of HDM2 and degradation of P53, which can promote tumor progression."
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"On the one hand, USP7 binds to and directly ubiquitinates p53, preventing its degradation."
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"On the other hand, knockdown of RORα further enhanced p53 ubiquitination, which was increased by the knockdown of HAUSP ( Figure 3 G)."
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"USP7 stabilizes MDM2 by deubiquitination, allowing MDM2 to ubiquitinate p53, leading to proteasomal degradation of p53."
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"According to previous findings, when it enters the nucleus, the GMPS-USP7 complex is formed with ubiquitin-specific protease 7 (USP7), which can promote the degradation of the p53 protein by deubiquitinating the negative p53 regulatory protein MDM2 [41,42]."
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"Moreover, we showed that CHIP knockdown abrogated the downregulation of p53 caused by USP7 knockdown (Fig. S5D), and simultaneous knockdown of CHIP and USP7 attenuated the enhanced ubiquitination of p53 in the cells subjected to USP7 knockdown (Fig. S5E)."
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"Fluorimetric quantification revealed that the USP7 and GMPS complex ubiquitylates p53 at a rate that is more than 20 times faster than USP7 alone (compare USP7 alone at 20 ' with USP7-GMPS at 1 ')."
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"First, ORF45 interacts with the p53 de-ubiquitinating enzyme USP7, which leads to increased p53 ubiquitination and degradation [43]."
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"Moderate down regulation of HAUSP reduces the deubiquitination of p53, leading to p53 destabilization and therefore favors cell proliferation [XREF_BIBR]."
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"We further determined whether ABRO1 facilitates p53 deubiquitination in a USP7 dependent manner; as shown in XREF_FIG, knockdown of USP7 impaired ABRO1 mediated p53 stability and deubiquitination."
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"USP7 preferentially causes the deubiquitination of MDM2 (an oncogenic E3 ligase), which subsequently causes ubiquitination of p53 (a tumor suppressor protein) and decreases its cellular level."
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"The expression of USP7/HAUSP prevents p53 ubiquitination from Mdm2 as a p53-specific E3 ligase and increases the p53 protein stability [25]."
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"Different strategies are being employed to achieve this, including Ube1 inhibition to prevent Ub activation, HDM2 inhibition to block p53 polyubiquitination, and USP7 and HAUSP inhibition to promote HDM2 degradation."
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"On one hand, p53 binds to TRAF domain and C-terminal (amino acids 880–1050) of USP7, and then USP7 ubiquitinates p53 directly and prevents it from degradation."
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