IndraLab

Statements

Modified USP7 increases the amount of TP53. 4 / 4
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"In addition, USP7 overexpression significantly increased endogenous Mdm2 and p53 levels, but had no effect on STIP levels (XREF_SUPPLEMENTARY)."
26460617
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"Expression of USP7, the target protein of EBNA1 and ICP0, however, effectively promotes increased levels of p53 by antagonizing proteasomal degradation of p53 through deubiquitination (Li et al., 2004)."
17291557
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"As shown by the Gu group, partial reduction of USP7 levels in several human cell lines promotes decreased levels of both MDM2 and p53, yet total abolition of USP7 stabilizes p53 levels by decreasing MDM2 [117, 118]."
24239534
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"Expression of USP7, the target protein of EBNA1 and ICP0, however, effectively promotes increased levels of p53 by antagonizing proteasomal degradation of p53 through deubiquitination."
17291557