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TP53 bound to TSPYL5 inhibits USP7. 1 / 1

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"In HEK293 cells, we observed that TSPYL5 could competitively bind to the N-terminal domain of deubiquitylase USP7 in conjunction with p53 and reduce the protective effects of USP7 on p53, resulting in ubiquitin mediated degradation of p53, and that the co-transfection of TSPY1 and TSPYL5 enhanced this effect."

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TP53 bound to TSPYL5 inhibits USP7. 1 / 1

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