IndraLab

Statements

TRAF binds TP53 and USP7. 2 / 2
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sparser
"As shown in xref , p53 has 393 amino acid residues that can be subdivided into five domains: the N-terminal transactivation domains (TAD) that are responsible for its binding to the p53-binding sites on MDM2 and MDMX, a proline-rich region (PP) that contains five PxxP motifs and is essential for inducing apoptosis, a DNA-binding domain (DBD), a tetramerization domain (TET), and a C-terminal domain (CTD) that is critical for the binding of p53 to the TRAF domain of USP7 ( xref ; xref )."
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sparser
"On one hand, p53 binds to TRAF domain and C-terminal (amino acids 880–1050) of USP7, and then USP7 ubiquitinates p53 directly and prevents it from degradation."
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