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"Although the essential role of USPs in protein degradation is well established, less is known about the function and regulation of specific family members: for example Usp7 has been associated with p53 and Akt turnover, Usp8 with receptor tyrosine endocytosis, Usp33 with the Von Hippel–Lindau disease (VHL) pathway and Usp19 is thought to have a role in muscle development [ xref ]."