IndraLab

Statements

TP53 activates USP7. 15 / 15
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"To determine whether there was increased apoptosis due to p53 activation in hausp knockout embryos, a TUNEL (TdT mediated dUTP Nick-End Labeling) assay was performed on wild-type and hausp knockout embryos of both days E6.5 (XREF_FIG) and E7.5 (XREF_FIG)."
19946331
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"Interestingly, the level of Mdm4 showed slight increase in hausp knockout MEFs (XREF_FIG, lane 6 versus lane 5), suggesting p53 activation in hausp knockout MEFs was mainly because of downregulation of Mdm2."
21350561
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"The results showed that knockout of p53 did not rescue the lethality of the hausp knockout."
19946331
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"10, 13, 14 The identification of these substrates indicates that USP7 controls additional vital cellular functions beyond those mediated by p53 stability."
33650720
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"We therefore observed p53 independent induction of p21 protein that was followed by cell-cycle arrest in G1 phase, as previously described."
22361354
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"Once again, the current study demonstrated the essential roles of p53 independent functions of HAUSP, indicated by the inability to rescue the neonatal lethality of hausp FL/FL; nes-cre mice by concomitant deletion of p53."
21350561
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"Hdm2 is preferentially targeted by USP7 over p53 under normal unstressed conditions; however, USP7 targets p53 in response to DNA damage."
25605410
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"Hausp knockout was partially rescued by p53 knockout."
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"Although deletion of p53 did not completely rescue the embryonic lethality of the hausp knockout, embryonic development was extended in both hausp and p53 double knockout embryos."
19946331
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"Owing to the observation of p53 activation in hausp knockout embryos, we attempted to rescue the lethality of hausp knockout mice by generating hausp and p53 double knockout mice."
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"The concurrent loss of TP53 effectively rescued the cytotoxic effect of USP7 knockout, as also observed for PPM1D knockout (XREF_FIG)."
30045945
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"Knockout of Usp7 in mice results in early embryonic lethality that can not be rescued by p53 knockout, suggesting additional roles of Usp7."
26365382
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"Loss of TP53 rescues the effects of MDM2, MDM4, PPM1D, and USP7 inhibition."
30045945
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"HAUSP plays pivotal roles in the stability of p53 and MDM2, raising HAUSP as a potential therapeutic target for tuning p53 mediated anti-tumor activity."
26077642
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"Knockout of Usp7 in mice results in early embryonic lethality that can not be rescued by p53 knockout, suggesting additional roles of Usp7 (Kon et al., 2010)."
26365382