IndraLab

Statements


USP7 bound to TP53 inhibits TP53. 2 / 2
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"Alternatively, during lytic replication, USP7 in the K-RTA-OTUD4-USP7 complex is activated to enable efficient viral replication, while USP7 in the USP7-p53 complex might be specifically targeted by vIRF1 and vIRF3 to negate the antiviral effect of p53 signaling."

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"Furthermore, EBNA-1-USP7 interaction prevents the binding of USP7 to p53 and thereby diminishes p53 stabilization."