IndraLab

Statements

TP53 binds USP7 and GMPS. 2 / 2
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"In the context of X-ray radiation, GMPS bound both USP7 and TP53 (Fig. xref b), and TP53 protein levels were elevated upon GMPS overexpression (Additional file xref : Figure S1e), suggesting that GMPS promotes TP53 protein stability."
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"Considering that the interaction among GMPS, USP7 with p53 is required for the deubiquitination and stabilization of p53 [ xref , xref ]. we next determined the interaction of GMPS and USP7 with p53 in the p53wt breast cancer cell lines MCF-7 and DU4475 by co-IP assays."
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