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TP53 deubiquitinates USP7. 2 / 2

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"It stabilizes p53 and induces p53-dependent apoptosis in cancer cells through inhibition of the p53-deubiquitinating enzyme USP7 [92]."

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"Knockdown of the p53 deubiquitinating enzyme USP7 and HAUSP also reverses the supervillin phenotype, blocking the increase in p53 levels seen after supervillin knockdown and accentuating the decrease in p53 levels triggered by supervillin overexpression."

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IndraLab

Statements

TP53 deubiquitinates USP7. 2 / 2

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