IndraLab

Statements

USP13 affects UIMC1
1 | 18
USP13 deubiquitinates UIMC1. 10 / 19
1 | 18
reach
"Together with results showing USP13 is important for DDR and RAP80 localization at the sites of DNA damage, we hypothesized that RAP80 ubiquitination is inhibitory of its function, and deubiquitination of RAP80 by USP13 following DNA damage promotes RAP80 function in the DDR pathway."
28569838
reach
"For example, deubiquitination of RAP80 by USP13 facilitates the interaction between RAP80 and polyubiquitin chain and is important for RAP80-BRCA1 foci formation and DNA repair [117]."
33990032
reach
"USP13 deubiquitinates receptor associated protein 80 (RAP80) and promotes DNA damage response."
33643919
reach
"USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR."
28569838
reach
"Deubiquitination of RAP80 by USP13 is important for DDR."
28569838
reach
"These results suggest that deubiquitination of RAP80 by USP13 following DNA damage facilitates the binding between RAP80 and K63- linked polyubiquitin chain."
28569838
reach
"We demonstrated that polyubiquitination of RAP80 blocks its interaction with polyubiquitin chain and deubiquitination of RAP80 by USP13 facilitate the interaction between RAP80 and polyubiquitin chain."
28569838
reach
"In addition, USP13 specific inhibitor, Spautin-1, significantly enhanced RAP80 ubiquitination in control but not USP13 deficient cells (XREF_FIG)."
28569838
reach
"USP13 interacts with and deubiquitinates RAP80."
28569838
ubibrowser
"USP13, in turn, deubiquitinates RAP80 and promotes RAP80 recruitment and proper DDR."
28569838
USP13 affects PTEN
1 | 8
USP13 deubiquitinates PTEN. 8 / 8
1 | 7
reach
"Therefore, USP13 can directly deubiquitinate PTEN."
24270891
reach
"Wild-type USP13 purified from either bacteria or 293T cells, but not its catalytically inactive mutant C345A, decreased PTEN poly-ubiquitination by 64-70% in vitro (XREF_FIG)."
24270891
reach
"USP13 deubiquitinates and stabilizes PTEN."
24270891
reach
"Deubiquitination and stabilization of PTEN by USP13."
24270891
reach
"Deubiquitination of PTEN by USP13, a deubiquitinating enzyme, stabilized PTEN, and thereby inhibited breast cancer tumorigenesis [5]."
25152374
ubibrowser
"Deubiquitylation and stabilization of PTEN by USP13"
24270891
reach
"Deubiquitylation and stabilization of PTEN by USP13."
24270891
reach
"On the other hand, ectopic expression of wild-type USP13, but not the C345A mutant which is still capable of interacting with PTEN (XREF_FIG), reduced the poly-ubiquitination of PTEN by 65% (XREF_FIG), suggesting that the enzymatic activity of USP13 is indispensable for USP13 dependent deubiquitination of PTEN."
24270891
Modified USP13 leads to the deubiquitination of PTEN. 1 / 1
| 1
reach
"On the other hand, ectopic expression of wild-type USP13, but not the C345A mutant which is still capable of interacting with PTEN (XREF_FIG), reduced the poly-ubiquitination of PTEN by 65% (XREF_FIG), suggesting that the enzymatic activity of USP13 is indispensable for USP13 dependent deubiquitination of PTEN."
24270891
USP13 affects MYC
1 | 8
USP13 deubiquitinates MYC. 5 / 5
1 | 4
reach
"Our data have demonstrated that USP13 mediates deubiquitination of c-Myc, whereas FBXL14 facilitates c-Myc ubiquitination in glioma cells."
27923907
reach
"Moreover, USP13 knockdown increased c-Myc ubiquitination, whereas FBXL14 knockdown reduced c-Myc ubiquitination (XREF_FIG)."
27923907
ubibrowser
"In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential."
27923907
reach
"The ubiquitination assay demonstrated that disruption of USP13 by shRNA markedly increased c-Myc ubiquitination and reduced c-Myc protein level in GSCs (XREF_FIG)."
27923907
reach
"Furthermore, USP13 can deubiquitinate and stabilise ACLY and OGDH and c-Myc in ovarian cancer and glioblastoma, respectively, thereby functioning as an oncogene [XREF_BIBR, XREF_BIBR]."
33627786
Modified USP13 leads to the deubiquitination of MYC. 2 / 2
| 2
reach
"Importantly, overexpression of USP13 together with FBXL14 abolished the increased c-Myc ubiquitination caused by FBXL14 overexpression (XREF_FIG, last lane)."
27923907
reach
"Overexpression of USP13 reduced c-Myc ubiquitination, and forced expression of FBXL14 increased c-Myc ubiquitination (XREF_FIG)."
27923907
Modified mutated USP13 leads to the deubiquitination of MYC. 1 / 1
| 1
reach
"Consistently, overexpression of the wild type but not the USP13 mutant reduced c-Myc ubiquitination and resulted in elevated c-Myc protein levels (XREF_FIG)."
27923907
USP13 leads to the deubiquitination of MYC. 1 / 1
| 1
reach
"As USP13 functions as a deubiquitinase that also interacts with c-Myc (XREF_FIG) and the preferential expression of USP13 in GSCs positively regulates c-Myc protein levels (XREF_FIG), we hypothesized that USP13 might mediate deubiquitination of c-Myc protein to prevent its degradation and stabilize c-Myc in GSCs."
27923907
USP13 affects BECN1
1 | 8
USP13 deubiquitinates BECN1. 9 / 9
1 | 8
reach
"Recent studies indicated that USP13 can deubiquitinate and regulate protein levels of Beclin-1, microphathalmia associated transcription factor, Siah2, phosphatase and tensin homolog, and STAT-1, and the deubiquitination process of USP13 could also be orchestrated by Beclin-1."
27923907
ubibrowser
"While A20 inhibits PtdIns3P signaling by removing the TRAF6-dependent Lys63-linked chains from Beclin 1, the enzymes USP10 and USP13 prevent PI3K-III complex components from their degradation and, therefore, support autophagy. Interestingly enough, USP10 also stabilizes p53, which, in turn, triggers the degradation of Beclin 1 and VPS34 in order to prevent autophagy."
26445063
reach
"USP10 and USP13 have been shown to mediate the deubiquitination of Beclin 1, thereby stabilizing the Vps34 complex XREF_BIBR."
24956373
reach
"Furthermore, the presence of spautin-1 inhibited the deubiquitination of Beclin1 mediated by USP10 and USP13."
21962518
reach
"We demonstrate that USP10 and USP13 can both mediate the deubiquitination of Beclin1."
21962518
reach
"It promotes the degradation of Vps34 complexes by inhibiting USP10 and USP13, two ubiquitin specific peptidases that target the deubiquitination of Beclin-1."
26530936
reach
"Likewise, USP13, which deubiquitinates BECN1 and stabilizes PIK3C3 complexes, is amplified in LUSQ."
26390342
reach
"Conversely, it was show that Beclin 1 is deubiquitinated by USP10 and USP13 and adding complexity, Beclin 1 itself controlled the protein stabilities of USP10 and USP13 by regulating their deubiquitinating activities, in turn regulating the levels of tumor suppressor p53 [XREF_BIBR]."
24729948
reach
"Specific and potent autophagy inhibitor-1 (Spautin-1) was identified to inhibit USP10 and USP13, which deubiquitinate the Beclin 1 subunit of Vsp34 complex, and thus promoted the degradation of Vsp34 PI3 kinase complex."
23797609
USP13 affects USP10
1 | 5
USP13 deubiquitinates USP10. 6 / 6
1 | 5
reach
"Moreover, beclin-1 and USP10 are involved in a potential feedforward mechanism in which beclin-1 stabilizes USP13, which in turn deubiquitinates and stabilizes USP10, leading to increased beclin-1 levels and activity."
33577797
ubibrowser
No evidence text available
reach
"Since USP13 can also deubiquitinate USP10, regulating the stability of USP13 by Beclin1 provides a mechanism for Beclin1 to control the stability of USP10."
21962518
reach
"These results suggest that USP13 may directly regulate the deubiquitination of USP10; however, USP10 may regulate USP13 indirectly perhaps by affecting the levels of Vps34 complexes."
21962518
reach
"Very interestingly, they also pointed out that beclin-1 controlled the stability of USP10 by regulating the stability of USP13, which can deubiquitinate USP10 (also see Figure 4) [53]."
35627217
reach
"Consistent with this possibility, the ubiquitination levels of USP10 were reduced when cells were cotransfected with an expression vector of USP13 and the addition of spautin-1 inhibited the deubiquitination of USP10 by USP13 (XREF_FIG)."
21962518
USP13 affects MCL1
1 | 5
USP13 deubiquitinates MCL1. 6 / 6
1 | 5
ubibrowser
"Collectively, we nominate USP13 as a novel deubiquitinase which regulates MCL1 turnover in diverse solid tumors and propose that USP13 may be a potential therapeutic target for the treatment of various malignancies."
29335437
reach
"Two DUBs USP9X and USP13 deubiquitinate and stabilise MCL1, and hypomorphic mutations in both have been linked to neurodevelopmental disorders and neurodegenerative disease [XREF_BIBR, XREF_BIBR]."
33414510
reach
"Next, we confirmed that USP13 deubiquitinated Mcl-1."
33627786
reach
"Therefore, USP13 interacted with and deubiquitinated MCL1 to preserve its protein stability."
29335437
reach
"USP13 interacts with and deubiquitinates Mcl-1 in cervical cancer cells."
33627786
reach
"USP13 interacts with and deubiquitinates MCL1."
29335437
USP13 affects ACLY
1 | 4
USP13 deubiquitinates ACLY. 4 / 4
1 | 3
reach
"Taken together, these studies suggest that USP14 is involved in the occurrence and progression of multiple malignant tumors.Other USP family members: USP13, the main regulator of ovarian cancer energy metabolism, specifically deubiquitinates and stabilizes oxoglutarate dehydrogenase and ATP citrate lyase, which can catalyze fatty acid synthesis, glutaminolysis and mitochondrial respiration."
30319415
ubibrowser
"USP13, the main regulator of ovarian cancer energy metabolism, specifically deubiquitinates and stabilizes oxoglutarate dehydrogenase and ATP citrate lyase, which can catalyze fatty acid synthesis, glutaminolysis and mitochondrial respiration."
30319415
reach
"Furthermore, USP13 can deubiquitinate and stabilise ACLY and OGDH and c-Myc in ovarian cancer and glioblastoma, respectively, thereby functioning as an oncogene [XREF_BIBR, XREF_BIBR]."
33627786
reach
"USP13 directly deubiquitinates ACLY and OGDH."
27892457
USP13-C345A leads to the deubiquitination of ACLY. 1 / 1
| 1
reach
"The C345A mutant of USP13 failed to reduce the ubiquitination of ACLY (XREF_FIG), suggesting that the deubiquitination activity is essential for the function of USP13."
27892457
USP13 affects STAT1
| 4
USP13 deubiquitinates STAT1. 4 / 4
| 4
reach
"Congruently, STAT1 ubiquitination is reduced in cells by USP13 overexpression and increased with USP13 knockdown regardless of IFNa treatment (115) ."
34707613
reach
"Congruently, STAT1 ubiquitination is reduced in cells by USP13 overexpression and increased with USP13 knockdown regardless of IFNα treatment (115)."
34707613
reach
"A recent report suggested that the deubiquitinase USP13 decreased STAT1 ubiquitination, which however was independent of IFNs treatment [XREF_BIBR]."
27434509
reach
"More specifically, USP13 positively regulates the antiviral activity of IFNa against DEN-2 virus replication by deubiquitinating and stabilizing STAT1 (115) ."
34707613
USP13 affects OGDH
1 | 3
USP13 deubiquitinates OGDH. 4 / 4
1 | 3
ubibrowser
"USP13, the main regulator of ovarian cancer energy metabolism, specifically deubiquitinates and stabilizes oxoglutarate dehydrogenase and ATP citrate lyase, which can catalyze fatty acid synthesis, glutaminolysis and mitochondrial respiration."
30319415
reach
"USP13 directly deubiquitinates ACLY and OGDH."
27892457
reach
"Furthermore, USP13 can deubiquitinate and stabilise ACLY and OGDH and c-Myc in ovarian cancer and glioblastoma, respectively, thereby functioning as an oncogene [XREF_BIBR, XREF_BIBR]."
33627786
reach
"Taken together, these studies suggest that USP14 is involved in the occurrence and progression of multiple malignant tumors.Other USP family members: USP13, the main regulator of ovarian cancer energy metabolism, specifically deubiquitinates and stabilizes oxoglutarate dehydrogenase and ATP citrate lyase, which can catalyze fatty acid synthesis, glutaminolysis and mitochondrial respiration."
30319415
USP13 affects STING1
1 | 2
USP13 leads to the deubiquitination of STING1. 2 / 2
1 | 1
reach
"Consistently, reconstitution of USP13 but not USP13 (AE) into Usp13 m/m MEFs inhibited HSV-1-induced ubiquitination of STING (XREF_FIG)."
28534493
ubibrowser
"Here, we show that ubiquitin-specific protease 13 (USP13) is a STING-interacting protein that catalyses deubiquitination of STING."
28534493
Mutated USP13 deubiquitinates STING1. 1 / 1
| 1
reach
"As expected, we found that USP13 but not the enzymatic inactive mutant USP13 (AE) catalysed deubiquitination of STING in cells or in vitro (XREF_FIG)."
28534493
USP13 affects SIGIRR
1 | 2
USP13 deubiquitinates SIGIRR. 2 / 2
| 2
reach
"We have shown that deubiquitination of Sigirr by USP13 increased Sigirr half-life (L. Li et al., 2019)."
33400290
reach
"The ubiquitination and degradation of Sigirr is negatively regulated by a deubiquitinase, USP13 (L. Li et al., 2019)."
33400290
USP13 deubiquitinates SIGIRR. 1 / 1
1 |
ubibrowser
"Stabilization of IL-1R8/Sigirr by USP13 describes a novel anti-inflammatory pathway in diseases that could provide a new strategy to modulate immune activation."
31204278
USP13 affects nsp13
| 2
USP13 deubiquitinates nsp13. 2 / 2
| 2
reach
"We found that nsp13 interacts with the deubiquitinase USP13, which deubiquitinates and stabilizes nsp13."
33707416
reach
"Loss of USP13 enhances ubiquitination of nsp13 and destabilizes nsp13 protein."
33707416
USP13 affects UBL4A
2 |
USP13 deubiquitinates UBL4A. 2 / 2
2 |
ubibrowser
"we identify USP13 as a gp78-associated DUB that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6."
24424410
ubibrowser
No evidence text available
USP13 affects SMAD4
| 2
USP13 deubiquitinates SMAD4. 2 / 2
| 2
reach
"USP13 stabilizes Smad4 by deubiquitinating Smad4.."
32434004
reach
"Knockdown of USP13 decreased Smad4 half-life and promoted Smad4 ubiquitination."
32434004
USP13 affects SIAH2
| 2
USP13 deubiquitinates SIAH2. 2 / 2
| 2
reach
"The DUB USP13 regulates Siah2 availability and activity as deubiquitination of Siah2 by USP13 results in a more stable, albeit less active, ubiquitin ligase."
23700162
reach
"Besides phosphorylation, Siah2 activity can be modulated by the deubiquitinating enzyme USP13, which binds to and deubiquitinates Siah2, increasing its stability but diminishing its activity toward its substrates."
29081737
USP13 affects Cyclin
| 2
USP13 deubiquitinates Cyclin on D1. 2 / 2
| 2
reach
"USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation."
37311811
reach
"Taken together, our data demonstrate that USP13 deubiquitinates and stabilizes cyclin D1, thereby promoting cell cycle progression and cell proliferation in GC."
37311811
USP13 affects Cohesin
| 2
USP13 leads to the deubiquitination of Cohesin. 1 / 1
| 1
reach
"Because ectopic overexpression of USP13 promoted deubiquitination of cohesin subunits, inactivation of USP13 was conversely expected to cause enhanced accumulation of ubiquitinated cohesin subunits."
33334891
USP13 leads to the deubiquitination of Cohesin on T293. 1 / 1
| 1
reach
"To investigate whether USP13 mediated the deubiquitination of cohesin subunits, we cotransfected 293T cells with expression vectors for His ubiquitin and Myc-USP13, purified ubiquitinated proteins by Ni-NTA affinity chromatography, and performed Western blot with antibodies to SMC3 and RAD21 (XREF_FIG A)."
33334891
USP13 affects ZHX2
| 1
USP13 leads to the deubiquitination of ZHX2. 1 / 1
| 1
reach
"USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer."
36037364
USP13 affects VCL
| 1
USP13 deubiquitinates VCL. 1 / 1
| 1
reach
"Future studies are warranted to determine the ubiquitination of vinculin in 293T cell lines and whether USP13 deubiquitinates vinculin polyubiquitylation and stabilizes vinculin protein."
28498477
USP13 affects TXNIP
| 1
USP13 deubiquitinates TXNIP. 1 / 1
| 1
reach
"This study is the first to reveal that USP13 may deubiquitinate and stabilize TXNIP."
34032995
USP13 affects TWIST1
| 1
USP13 deubiquitinates TWIST1. 1 / 1
| 1
reach
"We found that Twist1 can be de-ubiquitinated by USP13."
36732432
USP13 affects TCRalpha
| 1
USP13 leads to the deubiquitination of TCRalpha. 1 / 1
| 1
reach
"Although our results have not ruled out the possibility that USP13 may contribute to deubiquitination of TCRalpha with the assistance of a substrate recruiting adaptor in cells, the inability to deubiquitinate TCRalpha by purified USP13 suggests that the accumulation of ubiquitinated TCRalpha in USP13 knockdown cells is probably due to ERAD inhibition at a step downstream of ubiquitination, as shown in Bag6 depleted cells."
24424410
USP13 affects Stomach Neoplasms
| 1
USP13 deubiquitinates Stomach Neoplasms. 1 / 1
| 1
reach
"USP13 interacted with Snail to deubiquitinate and stabilize Snail in GC cells."
34872023
USP13 affects SNAI1
| 1
USP13 deubiquitinates SNAI1. 1 / 1
| 1
reach
"USP13 interacted with Snail to deubiquitinate and stabilize Snail in GC cells."
34872023
USP13 affects SKP2
1 |
USP13 deubiquitinates SKP2. 1 / 1
1 |
ubibrowser
No evidence text available
USP13 affects MITF
1 |
USP13 deubiquitinates MITF. 1 / 1
1 |
ubibrowser
"However, deubiquitinase?USP13 can stabilize?MITF?expression and prolong its half‐life."
28544818
USP13 affects AMFR
| 1
USP13 leads to the deubiquitination of AMFR. 1 / 1
| 1
reach
"The proper function of BAG6 seems to require the activity of the deubiquitinating enzyme USP13, which antagonizes gp78 mediated ubiquitination to ensure ERAD efficiency."
26424800