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USP13 deubiquitinates RAF1. 5 / 5
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"Sp-1 functions mainly by inhibiting the activity of USP13, which associates with and deubiquitinates RAF1."
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"USP13 deubiquitinates Raf1."
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"The abovementioned results indicated that USP13 deubiquitinates Raf1 to increase its stability, while Sp-1 antagonizes USP13 function and promotes Raf1 degradation."
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"Finally, the ubiquitination of HA-hRAF1 was examined in FLAG-hUSP13-expressing hiPSCs and the western blot results showed that USP13 suppressed RAF1 ubiquitination (Fig. 8H)."
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"Sp-1 mainly functions by inhibiting the deubiquitinating protein USP13, which interacts with and thereby deubiquitinates the Raf1 protein in the cells; the latter is a key component in the activation of MEK/ERK signaling (Fig. 9)."
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