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USP13 deubiquitinates PIK3C3. 3 / 4
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"Moreover, spautin-1, is another effective inhibitor, which impedes the initiation step of autophagy, by suppressing the crucial for the process ubiquitin-specific peptidases USP13, USP10, as well as Beclin-1, which is deubiquitinated in Vps34 complex[99]."
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"Meanwhile, an in vitro deubiquitination assay showed that USP13 inhibits the K48linked ubiquitination of PIK3C3 in the presence of NEDD4."
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"Interestingly, NEDD4-1 undergoes auto-ubiquitination that serves it as a scaffold for engaging the ubiquitin-specific protease 13 (USP13) to form a NEDD4-1/USP13 deubiquitination complex, which subsequently deubiquitinates and stabilizes VPS34 to induce phagophore nucleation in cancer cells."
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