IndraLab

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USP13 deubiquitinates ACLY. 7 / 8
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"USP13 directly deubiquitinates ACLY and OGDH."
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"In ovarian tumors, upregulation of USP13 enhances deubiquitination and stabilization of ACLY (ATP citrate lyase) and OGDH (oxoglutarate dehydrogenase), two key enzymes that drive glutaminolysis, ATP generation, and lipid synthesis in cancer metabolism , and MCL1, a pivotal member of the antiapoptotic BCL-2 family of proteins ."
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"Furthermore, USP13 can deubiquitinate and stabilise ACLY and OGDH and c-Myc in ovarian cancer and glioblastoma, respectively, thereby functioning as an oncogene [XREF_BIBR, XREF_BIBR]."
33627786
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"As it was aforementioned, USP13 deubiquitinates OGDH and ACLY."
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"Taken together, these studies suggest that USP14 is involved in the occurrence and progression of multiple malignant tumors.Other USP family members: USP13, the main regulator of ovarian cancer energy metabolism, specifically deubiquitinates and stabilizes oxoglutarate dehydrogenase and ATP citrate lyase, which can catalyze fatty acid synthesis, glutaminolysis and mitochondrial respiration."
30319415
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"USP13 influences cell cycle progression in gastric cancer by stabilizing cyclin D1 [15] and enhances the deubiquitination and stabilization of ATP citrate lyase (ACLY) and oxoglutarate dehydrogenase (OGDH) in ovarian tumors [16]."
40319251
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"Mechanistically, USP13 promoted the energy metabolism of tumor cells, and provided precursor substances for the synthesis of sugar, lipids and non-essential amino acids in cancer cells, through deubiquitinating and stabilizing ACLY and OGDH (Han et al., 2016)."
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