IndraLab

Statements


USP13 deubiquitinates METTL3 on K488. 3 / 3
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"Ubiquitin-specific proteases 13 (USP13) regulates glycolytic reprogramming and proliferation in osteosarcoma by deubiquitinating METTL3 at K488."

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"Our results indicated that USP13 promotes glycolytic reprogramming and progression in OS by stabilizing as well as deubiquitinating METTL3 protein at K488 by removing K48-linked ubiquitin chains, which further stabilizes ATG5 mRNA and activates oncogenic autophagy."

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"USP13 deubiquitinates METTL3 at K488 by removing K48-linked ubiquitin chains."