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USP13 leads to the deubiquitination of METTL3. 5 / 5
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"In contrast, overexpression of USP13 significantly decreased ubiquitination of METTL3 in HOS cells (Fig. S4a)."
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"Overexpression of WT USP13 decreased METTL3 ubiquitination while C345A mutant USP13 showed no significant effect (Fig. 4b)."
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"USP13 was shown to positively promote glycolysis and tumor progression by stabilizing and deubiquitinating METTL3, which is a well-known “writer” for m A modification, at K488 by removing K48-linked ubiquitin chains."
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"In this study, we found that USP13 interacts with METTL3 and decreases METTL3 ubiquitination, resulting in reduced METTL3 degradation in OS."
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"Depletion of USP13 significantly promoted METTL3 ubiquitination level compared with shNC in 143B cells (Fig. 4a)."
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