IndraLab

Statements

USP13 deubiquitinates ZHX2. 12 / 12
| 12
reach
"USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer."
36037364
reach
"However, a deubiquitinase USP13 inhibits the ubiquitination of ZHX2 and enhances its stability (15)."
36465389
reach
"Next, we tried to examine whether USP13 can act as a DUB for ZHX2 and promote ZHX2 deubiquitination and protein stability in ccRCC cells."
36037364
reach
"Under denaturing conditions, we found that USP13 WT overexpression led to decreased ZHX2 ubiquitination in ccRCC cell lines (UMRC-2 and 786-O) (Fig. 1M)."
36037364
reach
"Interestingly, USP13 has also been implicated in renal cancer, but rather than altering HIF activity, USP13 deubiquitinates another VHL target gene and oncogenic driver, ZHX2 [141]."
39584532
reach
"In these two cells, USP13 depletion by two USP13 short hairpin RNA increased the ZHX2 ubiquitination level (Fig. 2 J and K)."
36037364
reach
"In conclusion, our results suggest that USP13 depletion down-regulated the ZHX2 level by increasing ZHX2 ubiquitination and degradation."
36037364
reach
"In addition, USP13 promotes tumorigenesis of clear cell renal cell carcinoma through deubiquitinating ZHX2 ."
38937512
reach
"19 Similarly, the process of ZHX2 deubiquitination catalyzed by USP13 is the committed step in the tumorigenesis of ccRCC."
38847328
reach
"It was found that USP13 could deubiquitinate zinc fingers and homeoboxes 2 (ZHX2) and stabilize ZHX2 protein."
40225869
reach
"In these tumors, USP13 deubiquitinates and stabilizes some oncogenes, including MCL1 [19, 20], Myc [8], MITF [21] and ZHX2 [22]."
37311811
reach
"Xie et al. revealed that USP13 can deubiquitinate and stabilize ZHX2 to promote the tumorigenesis of clear cell renal cell carcinoma [33]."
40319251