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USP13 deubiquitinates STAT1. 6 / 6
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"For example, USP13 regulates antiviral responses by deubiquitinating STAT1 and STING (Sun et al. 2017; Yeh et al. 2013) and is related to PTEN and MITF in the modulation of tumorigenesis (Zhang et al. 2013; Zhao et al. 2011)."
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"We detected that overexpression of USP13 attenuated the ubiquitination of STAT1, reversing the MBTPS1-induced increase in STAT1 ubiquitination, reduction in stability, and subsequent decrease in STAT1 protein levels (Fig. 7i–k)."
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"This finding was consistent with the findings of a recent study showing that USP13 deubiquitinates STAT1 ."
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"This competition subsequently interfered with the deubiquitination of STAT1 by USP13, promoting its degradation via the ubiquitin‒proteasome pathway."
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"Congruently, STAT1 ubiquitination is reduced in cells by USP13 overexpression and increased with USP13 knockdown regardless of IFNα treatment (115)."
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"A recent report suggested that the deubiquitinase USP13 decreased STAT1 ubiquitination, which however was independent of IFNs treatment [XREF_BIBR]."
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