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USP13 deubiquitinates MCL1. 12 / 12
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"USP13, on the other hand, can deubiquitinate and stabilize MCL1, which is not sensitive to MCL-2 family inhibitors, and render tumor cells highly resistant to BH3-type chemotherapy drugs (Oltersdorf et al., 2005; Delbridge et al., 2016; Kotschy et al., 2016)."
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"USP13 interacts with and deubiquitinates Mcl-1 in cervical cancer cells."
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"Next, we confirmed that USP13 deubiquitinated Mcl-1."
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"Collectively, we nominate <span class="match term0">USP13</span> as a novel deubiquitinase which regulates <span class="match term1">MCL1</span> turnover in diverse solid tumors and propose that <span class="match term0">USP13</span> may be a potential therapeutic target for the treatment of various malignancies."
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"Two DUBs USP9X and USP13 deubiquitinate and stabilise MCL1, and hypomorphic mutations in both have been linked to neurodevelopmental disorders and neurodegenerative disease [XREF_BIBR, XREF_BIBR]."
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"USP13 interacts with and deubiquitinates MCL1."
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"Another study has shown that USP13 is essential for HPV-positive cervical cancer cells to proliferate, at least in part by deubiquitinating and stabilizing the prosurvival protein Mcl-1 [122]."
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"Therefore, USP13 interacted with and deubiquitinated MCL1 to preserve its protein stability."
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"USP13 interacts with MCL1 and stabilizes its expression by deubiquitinating MCL1."
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"Morgan et al. (2021) demonstrated that USP13 deubiquitinates and stabilizes Mcl-1, promoting the proliferation in cervical cancer."
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"In these tumors, USP13 deubiquitinates and stabilizes some oncogenes, including MCL1 [19, 20], Myc [8], MITF [21] and ZHX2 [22]."
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"Morgan et al. further revealed that USP13 enhances cervical cancer cell growth via the deubiquitination of Mcl-1 [34]."
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