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EMMAA Bob with Bioagents

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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP13 deubiquitinates MCL1. 6 / 6

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"Collectively, we nominate USP13 as a novel deubiquitinase which regulates MCL1 turnover in diverse solid tumors and propose that USP13 may be a potential therapeutic target for the treatment of various malignancies."

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"Two DUBs USP9X and USP13 deubiquitinate and stabilise MCL1, and hypomorphic mutations in both have been linked to neurodevelopmental disorders and neurodegenerative disease [XREF_BIBR, XREF_BIBR]."

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"Next, we confirmed that USP13 deubiquitinated Mcl-1."

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"Therefore, USP13 interacted with and deubiquitinated MCL1 to preserve its protein stability."

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"USP13 interacts with and deubiquitinates Mcl-1 in cervical cancer cells."

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"USP13 interacts with and deubiquitinates MCL1."

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