IndraLab

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USP13 leads to the deubiquitination of PRKN. 2 / 2
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"Here, it was shown that USP13 negatively regulates Parkin ubiquitination, function, and solubility (Figure 5), negatively regulates the level, ubiquitination, and clearance of α-synuclein, and regulates proteasome activity independently of Parkin, which affects dopaminergic neuronal viability and motor performances in animal models."
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"Second, USP13 knockdown can increase Parkin ubiquitination and activity, thereby reducing the level of α-Syn; the excessive expression of USP13 increases the expression of α-Syn [68,69]."
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