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USP13 deubiquitinates STING1. 5 / 5
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reach
"The USP family of DUBs is very important, with USP13, USP18, USP20, USP21, USP44, and USP49 shown to mediate the deubiquitination of STING (Chen et al., 2021)."
36579404
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"Consistently, reconstitution of USP13 but not USP13 (AE) into Usp13 m/m MEFs inhibited HSV-1-induced ubiquitination of STING (XREF_FIG)."
28534493
ubibrowser
"Here, we show that ubiquitin-specific protease 13 (<span class="match term0">USP13</span>) is a STING-interacting protein that catalyses deubiquitination of <span class="match term1">STING</span>."
28534493
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"For example, USP13 regulates antiviral responses by deubiquitinating STAT1 and STING (Sun et al. 2017; Yeh et al. 2013) and is related to PTEN and MITF in the modulation of tumorigenesis (Zhang et al. 2013; Zhao et al. 2011)."
36585612
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"In addition, USP13 negatively modulates antiviral immunity by deubiquitinating STING, and targeting USP13 consequently triggers STING-interferon signaling and strengthens innate immunity [26]."
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