IndraLab

Statements

USP13 deubiquitinates TLR4. 3 / 3
| 3
reach
"In more detail, Gao et al. demonstrated that USP13 potentiated the deubiquitination and the stabilization of TLR4, activating the TLR4/MyD88/NF-κB pathway under hypoxic conditions."
37345131
reach
"Hypoxia-induced ubiquitin-specific peptidase 13 (USP13) deubiquitinated and stabilized toll-like receptor 4 (TLR4) to activate the myeloid differentiation primary response gene 88/nuclear factor-κB (MyD88/NF-κB) pathway, thereby contributing to HCC progression (Gao et al., 2020)."
35721496
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"USP13 knockdown increases TLR4 ubiquitination, leading to its decreased expression, which results in the decreased expression of MYD88, phosphorylated-NF-κB and p65, thus inhibiting the proliferation and invasion of HCC cells."
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