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USP13 deubiquitinates WWP1. 5 / 5
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"YY1 induced USP13 transcriptional activation drives the malignant progression of hepatocellular carcinoma by deubiquitinating WWP1."
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"USP13 deubiquitinated and regulated WWP1 in a proteasomal-dependent way.."
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"As shown in Fig. 4I, the HA-Ub mutants K27R, K48R, and K63R attenuated the deubiquitination of WWP1 by USP13."
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"By acting as a DUB, USP13 can bind to and then deubiquitinate and stabilize the WWP1 protein, thus activating the Akt/mTOR pathway."
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"Here, we revealed that USP13, which acts as a DUB, deubiquitinates WWP1, which was identified as a new substrate of USP13."
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