IndraLab

Statements

OTUB1 affects UBE2E1
2 | 7
OTUB1 leads to the deubiquitination of UBE2E1. 9 / 9
2 | 7
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"We show that OTUB1 suppresses UBE2E1 autoubiquitination in vitro and in cells, thereby preventing UBE2E1 from being targeted to the proteasome for degradation."
30282802
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"We show here that OTUB1 noncatalytically inhibits UBE2E1 autoubiquitination in vitro in either the presence or absence of E3 ligase (Fig. 4)."
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"OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination"
30282802
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"Although it is not known whether RNF4 stimulates UBE2E1 in vivo, our in vitro results raised the interesting possibility that OTUB1 could inhibit UBE2E1 autoubiquitination in cells, thereby accounting for the ability of OTUB1 to prevent UBE2E1 from being targeted to the proteasome."
30282802
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"Catalytically inactive OTUB1 completely inhibits UBE2E1 ubiquitination activity in both the presence and absence of E3 (Fig. 4, top panel)."
30282802
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"A recent study showed that OTUB1 also prevents autoubiquitylation of UBE2E1, thereby rescuing the E2 from proteasomal degradation 35."
32049508
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"We find that OTUB1 depletion dramatically destabilizes the E2-conjugating enzyme UBE2E1 (UBCH6) in both mouse and human OTUB1 knockout cell lines."
30282802
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"OTUB1 inhibits UBE2E1 autoubiquitination."
30282802
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"OTUB1 inhibits auto-monoubiquitylation of UBE2E1 and UBE2E2 but not UBE2E3."
32049508
OTUB1 affects TRAF3
1 | 8
OTUB1 deubiquitinates TRAF3. 9 / 9
1 | 8
ubibrowser
"Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6"
19996094
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
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"Knockout of HSCARG attenuated the de-ubiquitination of TRAF3 by OTUB1, and knockdown of OTUB1 abolished the effect of HSCARG."
24763515
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"Furthermore, we found that OTUB1 and OTUB2 mediated virus triggered deubiquitination of TRAF3 and -6."
19996094
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"Collectively, OTUB1 deubiquitinates TRAF3 to activate NLRP3 inflammasome, thereby leading to inflammation and remodeling of TGF-β1-induced cells, and further promoting the pathogenesis of asthma."
36976509
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus-induced IFN-β expression and cellular antiviral responses (53)."
28717359
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
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"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
OTUB1 affects TP53
1 | 7
OTUB1 leads to the deubiquitination of TP53. 8 / 8
1 | 7
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"OTUB1 blocks p53 ubiquitylation by MDM2 by interacting with and inhibiting UbcH5, and E2 conjugating enzyme for MDM2."
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"Review"
27919796
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"Interestingly, Otub1 abrogates p53 ubiquitination and stabilizes and activates p53 in cells independently of its deubiquitinating enzyme activity."
24920999
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"For example, USP7 modulates the stability of both p53 and MDM2, and maintains the level of p53 ubiquitylation; USP2 affects the stability of MDM2; Otub1 inhibits p53 ubiquitination and activates p53 in cells; USP10 regulates the location and stability of p53, and stabilize both mutated and wild-type p53, thereby having a dual role in tumorigenesis."
33643919
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"However, Otub1 decreases p53 ubiquitination, stabilizing and activating p53 in cells via inhibition of UbcH5, a cognate ubiquitin-conjugating enzyme of MDM2."
32532965
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"Otub1, a DUB from the OTU-domain containing protease family abrogates p53 ubiquitination and stabilizes and activates p53 in cells independent of its deubiquitinating enzyme activity [XREF_BIBR]."
25972356
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"Examples for DUBs that might antagonize E4 dependent polyubiquitylation are USP47, a regulator of Base Excision Repair (BER) that controls DNA polymerase beta and OTUB1, which mediates DNA damage dependent deubiquitylation of p53 and MDM2 in the cytoplasm."
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"For example, USP7 regulates the stability of both p53 and Mdm2 and maintains p53 ubiquitination levels; 120 USP2 mediates the stability of Mdm2; 121 USP10 modulates p53 localization and stability; 122 OTUB1 abrogates p53 ubiquitination and activates p53."
32140262
OTUB1 affects FOXM1
1 | 7
OTUB1 deubiquitinates FOXM1. 6 / 6
1 | 5
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"29 We have shown previously that OTUB1 can specifically limit FOXM1 polyubiquitination and its degradation, through its deubiquitinase enzymatic activity."
27526106
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"Conversely, the invitro deubiquitination assays revealed that both OTUB1 (WT) and OTUB1 (D88A), but not OTUB1 (C91A), could efficiently deubiquitinate FOXM1 (XREF_FIG C, invitro Deub, lanes 5-8), as expected."
33640455
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"Taken together, the results provided strong evidence that OTUB1 suppresses FOXM1 ubiquitination and degraduation."
26148240
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"OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer"
27167337
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"Moreover, OTUB1 can deubiquitinate and stabilize the forkhead transcription factor FOXM1, which promotes DNA damage response and genotoxic drug resistance in breast cancer."
27844253
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"OTUB1 mediates the deubiquitination of FOXM1 to promote renal cancer tumor progression (Zhou et al., 2020)."
36339263
OTUB1-D88A deubiquitinates FOXM1. 1 / 1
| 1
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"Conversely, the invitro deubiquitination assays revealed that both OTUB1 (WT) and OTUB1 (D88A), but not OTUB1 (C91A), could efficiently deubiquitinate FOXM1 (XREF_FIG C, invitro Deub, lanes 5-8), as expected."
33640455
OTUB1-C91A deubiquitinates FOXM1. 1 / 1
| 1
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"Conversely, the invitro deubiquitination assays revealed that both OTUB1 (WT) and OTUB1 (D88A), but not OTUB1 (C91A), could efficiently deubiquitinate FOXM1 (XREF_FIG C, invitro Deub, lanes 5-8), as expected."
33640455
OTUB1 affects TRAF6
1 | 5
OTUB1 deubiquitinates TRAF6. 6 / 6
1 | 5
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
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"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus-induced IFN-β expression and cellular antiviral responses (53)."
28717359
ubibrowser
"Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6"
19996094
reach
"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
OTUB1 affects RAS
| 6
OTUB1 leads to the deubiquitination of RAS. 6 / 6
| 6
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"OTUB1 inhibits RAS ubiquitination independently of its catalytic activity resulting in sequestration of RAS on the plasma membrane."
26881969
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"In fact, invitro ubiquitination of RAS was abolished by wt OTUB1, but not by deltaN (1-30) OTUB1-mutant lacking binding to E2 (Fig XREF_FIG A)."
26881969
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"Consistent with the observation that OTUB1 inhibits RAS ubiquitination, analysis of RAS localization revealed that OTUB1 overexpression augmented the presence of RAS proteins on the plasma membrane (Fig XREF_FIG E and F; XREF_SUPPLEMENTARY)."
26881969
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"OTUB1 triggers activation of the MAPK pathway by inhibiting RAS ubiquitination."
26881969
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"Therefore, we tested whether the catalytic activity of OTUB1 is essential to promote RAS de-ubiquitination."
26881969
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"OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination."
26881969
OTUB1 affects MSH2
| 5
OTUB1 leads to the deubiquitination of MSH2. 5 / 5
| 5
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"These results strongly suggest that OTUB1 blocks MSH2 ubiquitination by inhibiting the E2 ligase activity, rather than by directly deubiquitinating MSH2."
33640455
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"Collectively, these results suggest that MSH2 is a substrate of OTUB1 and that OTUB1 inhibits MSH2 ubiquitination."
33640455
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"We therefore conclude that OTUB1 prevents MSH2 ubiquitination by suppressing the E2 ligase activity."
33640455
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"OTUB1 inhibits the ubiquitination of MSH2."
33640455
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"It is possible that OTUB1 prevents MSH2 ubiquitination by inhibiting the E2 activity of HDAC6 or by competing with HDAC6 for the MSH2 residues located in the central domain."
33640455
OTUB1 affects SMAD3
1 | 3
OTUB1 deubiquitinates SMAD3. 3 / 3
1 | 2
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"OTUB1 could not directly de-ubiquitinate Smad2 and Smad3, while its effect is dependent on regulating ubiquitin E2 conjugating-enzyme activity."
27604640
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"OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3."
24071738
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"OTUB1 prevents SMAD3 ubiquitylation."
24071738
Ubiquitinated OTUB1 leads to the deubiquitination of SMAD3. 1 / 1
| 1
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"In contrast, OTU domain, ubiquitin aldehyde binding 1 (OTUB1), B-cell lymphoma-3 (BCL-3), ubiquitin carboxyl-terminal hydrolase 1 (UCHL1), and UCHL5 contribute to the deubiquitination of SMAD2 or SMAD3, making them more stable and less easily degradable and promoting TGF-beta signaling [XREF_BIBR - XREF_BIBR]."
34335834
OTUB1 affects SMAD2_3
| 4
OTUB1 deubiquitinates SMAD2_3. 3 / 3
| 3
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"These results imply that OTUB1 inhibits the ubiquitylation of SMAD2/3 rather than directly deubiquitylating them."
24071738
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"Interestingly, it was found that the mechanism is non canonical and non catalytic : instead of OTUB1 directly deubiquitinating SMAD2/3 rather it interacts with the E2 ligases prevents the transfer of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28923280
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"This led us to hypothesize that OTUB1 might inhibit the ubiquitylation of SMAD2/3."
24071738
Mutated OTUB1 leads to the deubiquitination of SMAD2_3. 1 / 1
| 1
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"Further, some catalytically inactive mutants of OTUB1, including OTUB1 C91S, were also able to inhibit SMAD2/3 ubiquitylation in vitro (XREF_FIG)."
24071738
OTUB1 affects SMAD2
1 | 3
OTUB1 deubiquitinates SMAD2. 3 / 3
1 | 2
ubibrowser
"OTUB1 enhances TGFbeta signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3."
24071738
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"OTUB1 could not directly de-ubiquitinate Smad2 and Smad3, while its effect is dependent on regulating ubiquitin E2 conjugating-enzyme activity."
27604640
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"Recently, OTUB1, a DUB, was reported to reduce poly-ubiquitination of Smad2 and Smad3 through inhibition of the E2 ubiquitin conjugating enzymes."
27604640
Ubiquitinated OTUB1 leads to the deubiquitination of SMAD2. 1 / 1
| 1
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"In contrast, OTU domain, ubiquitin aldehyde binding 1 (OTUB1), B-cell lymphoma-3 (BCL-3), ubiquitin carboxyl-terminal hydrolase 1 (UCHL1), and UCHL5 contribute to the deubiquitination of SMAD2 or SMAD3, making them more stable and less easily degradable and promoting TGF-beta signaling [XREF_BIBR - XREF_BIBR]."
34335834
OTUB1 affects RNF168
| 4
OTUB1 leads to the deubiquitination of RNF168. 4 / 4
| 4
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"Finally, the DUB OTUB1 inhibits RNF168 mediated ubiquitylation in a non catalytic fashion by binding to UBC13 and inhibiting the formation of Lys63 linked poly-ubiquitin chains [35 **]."
22464734
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"It has been reported that OTUB1 suppresses RNF168 dependent poly-ubiquitination by binding to and inhibiting UBC13, but independently of OTUB1 catalytic activity as a deubiquitinating enzyme (Nakada e[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27345151
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"Indeed, the ability of OTUB1 to inhibit RNF168 dependent ubiquitylation is independent of its catalytic activity, and is instead mediated by its binding to and inhibition of the E2 UBC13, which cooperates with RNF168, suggesting that E2 regulation could also represent a means to regulate the DDR pathway."
23847653
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"Remarkably, the ability of OTUB1 to inhibit RNF168 dependent ubiquitylation was independent of its catalytic activity, suggesting an unusual mechanism of action."
21056014
OTUB1 affects UBE2N
1 | 2
OTUB1 leads to the deubiquitination of UBE2N. 3 / 3
1 | 2
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"Since, OTUB1 inhibits UBC13 dependent polyubiquitylation but not monoubiquitylation, it may be that a single ubiquitin conjugated to another protein at DSBs is sufficient to be recognized by the MIU d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21130715
ubibrowser
"Although OTUB1 is not catalytically involved in deubiquitinating these K63-linked chains, it may interact with Ubc13 and inhibit the E3 ligase RNF168"
25121098
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"As shown in Fig. 3e, OTUB1 reduced the K48-linked ubiquitination of UBC13 in TgPFN-stimulated BMDCs."
32024978
OTUB1 affects TPM2
| 2
OTUB1 deubiquitinates TPM2. 2 / 2
| 2
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"For DA1 and DA2, their transcription is most likely regulated by OTU1 that acts as a transcriptional corepressor, deubiquitylating the DA1 and DA2 chromatin."
32169818
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"OTU1 Is Involved in Deubiquitylation of the DA1 and DA2 Chromatin."
32169818
OTUB1 affects MYC
| 2
OTUB1 deubiquitinates MYC. 1 / 1
| 1
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"Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis."
35296795
OTUB1 deubiquitinates MYC on K323. 1 / 1
| 1
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"OTUB1 could directly deubiquitinate MYC at K323 site, which blocks MYC protein degradation."
35296795
OTUB1 affects MAPT
1 | 1
OTUB1 deubiquitinates MAPT. 2 / 2
1 | 1
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"We demonstrate here for the first time that Tau is deubiquitinated by Otub1."
28083634
ubibrowser
"Focusing on Tau deubiquitination, we here identify Otub1 as a Tau-deubiquitinating enzyme. Otub1 directly affected Lys48-linked Tau deubiquitination"
28083634
OTUB1 affects Histone
| 2
OTUB1-C91S leads to the deubiquitination of Histone. 1 / 1
| 1
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"However, the inhibitory effect of OTUB1 is independent of its DUB activity because the catalytically inactive mutant OTUB1 C91S suppresses 53BP1 IRIF and core histone ubiquitination as efficiently as wild-type OTUB1 [XREF_BIBR]."
26983989
Modified OTUB1 leads to the deubiquitination of Histone. 1 / 1
| 1
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"Whereas the exogenous expression of OTUB1 completely abrogated RNF168 dependent histone ubiquitination, the exogenous expression of OTUB2 did not affect the histone ubiquitination level."
24560272
OTUB1 affects ESR1
1 | 1
OTUB1 deubiquitinates ESR1. 2 / 2
1 | 1
ubibrowser
No evidence text available
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"OTUB1 deubiquitinates ERalpha in vitro and in vivo and stabilizes ERalpha in the nucleus [XREF_BIBR]."
27844253
OTUB1 affects DDX58
| 2
OTUB1 leads to the deubiquitination of DDX58. 2 / 2
| 2
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"NS1 is the most important IFNs antagonist protein via mechanisms including inhibition of the TRIM25 mediated RIG-I ubiquitination, suppression of protein kinase R (PKR), phosphorylation of IkappaB kinases (IKK) alpha and beta in the NF-kappaB pathway, interruption of the phosphorylation of STAT1, STAT2, and STAT3 [XREF_BIBR, XREF_BIBR], and degradation of OTUB1 [XREF_BIBR]."
32235330
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"NS1 is the most important IFNs antagonist protein via mechanisms including inhibition of the TRIM25-mediated RIG-I ubiquitination, suppression of protein kinase R (PKR), phosphorylation of IκB kinases (IKK) α and β in the NF-κB pathway, interruption of the phosphorylation of STAT1, STAT2, and STAT3 [39, 115] , and degradation of OTUB1 [138] ."
32235330
OTUB1 affects polyUb-protein
| 1
OTUB1 leads to the deubiquitination of polyUb-protein. 1 / 1
| 1
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"The high K48-linkage selectivity of hOtu1 on free polyUb chains led us to investigate deubiquitination of polyUb protein conjugates."
19211026
OTUB1 affects phospho-Smad2/3
| 1
OTUB1 leads to the deubiquitination of phospho-Smad2/3. 1 / 1
| 1
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"12 OTUB1 inhibits the ubiquitination of phospho-Smad2/3 by binding to and inhibiting the E2 ubiquitin conjugating enzymes, independent of its deubiquitinase activity."
27906182
OTUB1 affects phospho-SMAD2/3
| 1
OTUB1 leads to the deubiquitination of phospho-SMAD2/3. 1 / 1
| 1
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"OTUB1 inhibits the ubiquitylation of phospho-SMAD2/3 by binding to and inhibiting the E2 ubiquitin conjugating enzymes independent of its catalytic activity."
24071738
OTUB1 affects forkhead
| 1
OTUB1 deubiquitinates forkhead. 1 / 1
| 1
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"Moreover, OTUB1 can deubiquitinate and stabilize the forkhead transcription factor FOXM1, which promotes DNA damage response and genotoxic drug resistance in breast cancer."
27844253
OTUB1 affects UBE2E3
| 1
OTUB1 leads to the deubiquitination of UBE2E3. 1 / 1
| 1
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"These results suggest that OTUB1 may serve to primarily inhibit polyubiquitination of UBE2E3, but not autoubiquitylation."
32049508
OTUB1 affects TGFBI
| 1
OTUB1 deubiquitinates TGFBI. 1 / 1
| 1
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"OTUB1 deubiquitinates TGFBI in a catalytic-independent manner and promotes angiogenesis in infantile hemangiomas by regulating glycolysis."
36994729
OTUB1 affects TGFB
| 1
OTUB1 leads to the deubiquitination of TGFB. 1 / 1
| 1
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"OTUB1, a member of the OTU family of DUBs, has been shown to inhibit the ubiquitylation of only TGFbeta activated SMAD2/3 XREF_BIBR."
25007997
OTUB1 affects SNAI1
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OTUB1 deubiquitinates SNAI1. 1 / 1
1 |
ubibrowser
"Functionally, OTUB1 facilitates metastasis of esophageal squamous cell carcinoma (ESCC) through promoting Snail protein stability."
29559747
OTUB1 affects SMAD2/3/4
| 1
OTUB1 deubiquitinates SMAD2/3/4. 1 / 1
| 1
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"Wild-type OTUB1 and the DeltaN mutant, both capable of cleaving K48 linked di- or polyubiquitin chains in vitro, along with all the catalytically inactive mutants (D88A, C91S, H265A, D/H, D/C/H, K71R) were not able to deubiquitylate the polyubiquitylated FLAG and SMAD2/3/4 complex (XREF_FIG)."
24071738
OTUB1 affects RPA1
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OTUB1 deubiquitinates RPA1. 1 / 1
1 |
ubibrowser
"PTEN recruits the deubiquitinase OTUB1 to mediate RPA1 deubiquitination."
26403191
OTUB1 affects MDM2
| 1
OTUB1 leads to the deubiquitination of MDM2. 1 / 1
| 1
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"Examples for DUBs that might antagonize E4 dependent polyubiquitylation are USP47, a regulator of Base Excision Repair (BER) that controls DNA polymerase beta and OTUB1, which mediates DNA damage dependent deubiquitylation of p53 and MDM2 in the cytoplasm."
25806049
OTUB1 affects Histone_H2B
| 1
OTUB1 deubiquitinates Histone_H2B. 1 / 1
| 1
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"It makes biological sense, therefore, that OTU1 acts to deubiquitylate H2B in the target genes' chromatin; in this scenario, H2B monoubiquitylation in the DA1 and DA2 chromatin should increase in the OTU1 loss-of-function mutants."
32169818
OTUB1 affects FLAG
| 1
OTUB1 deubiquitinates FLAG. 1 / 1
| 1
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"Wild-type OTUB1 and the DeltaN mutant, both capable of cleaving K48 linked di- or polyubiquitin chains in vitro, along with all the catalytically inactive mutants (D88A, C91S, H265A, D/H, D/C/H, K71R) were not able to deubiquitylate the polyubiquitylated FLAG and SMAD2/3/4 complex (XREF_FIG)."
24071738
OTUB1 affects FGFR2
| 1
OTUB1 leads to the deubiquitination of FGFR2. 1 / 1
| 1
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"OTUB1 attenuates the E3 ligase SMURF1-mediated FGFR2 ubiquitination by inhibiting SMURF1's E2 binding."
37024477
OTUB1 affects EYA1
| 1
OTUB1 deubiquitinates EYA1. 1 / 1
| 1
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"Mechanistically, OTUB1 could interact with EYA1 directly and deubiquitinate EYA1 to stabilize it."
34773364
OTUB1 affects E3 ubiquitin
| 1
OTUB1 deubiquitinates E3 ubiquitin. 1 / 1
| 1
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"OTUB1 also deubiquitinates some E3 ubiquitin ligases, such as c-IAP1, a regulator of NF-κB and mitogen-activated protein kinase signaling pathways (14), TRAF3 and TRAF6, regulators of virus-triggered interferon induction (15), and GRAIL, which regulates T-cell anergy (16)."
30282802
OTUB1 affects E2F1
| 1
OTUB1 leads to the deubiquitination of E2F1. 1 / 1
| 1
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"Furthermore, the OTUB1 knockdown significantly reversed the decreased ubiquitination of E2F1 induced by the overexpression of TMPO-AS1 in RT4 and T24 cells (XREF_FIG)."
33816295
OTUB1 affects DEPTOR
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OTUB1 deubiquitinates DEPTOR. 1 / 1
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ubibrowser
"OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR"
29382726
OTUB1 affects DCN
| 1
Modified OTUB1 leads to the deubiquitination of DCN. 1 / 1
| 1
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"The overexpression of OTUB1 enhanced the ubiquitination and degradation of DCN in MC."
22279542
OTUB1 affects DA2
| 1
OTUB1 deubiquitinates DA2. 1 / 1
| 1
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"For DA1 and DA2, their transcription is most likely regulated by OTU1 that acts as a transcriptional corepressor, deubiquitylating the DA1 and DA2 chromatin."
32169818
OTUB1 affects DA2 Chromatin
| 1
OTUB1 deubiquitinates DA2 Chromatin. 1 / 1
| 1
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"OTU1 Is Involved in Deubiquitylation of the DA1 and DA2 Chromatin."
32169818
OTUB1 affects BIRC2
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OTUB1 deubiquitinates BIRC2. 1 / 1
1 |
ubibrowser
"Here, we describe the identification of OTUB1 as a c-IAP-associated deubiquitinating enzyme that regulates c-IAP1 stability. OTUB1 disassembles K48-linked polyubiquitin chains from c-IAP1 in vitro and in vivo within the TWEAK receptor-signalling complex."
23524849