IndraLab

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OTUB1 deubiquitinates SNAI1. 2 / 3
1 | 2

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"Further study showed that OTUB1 interacts with SNAIL, directly deubiquitinates SNAIL, and promotes SNAIL protein stability (Zhou et al., 2018)."

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"Deubiquitinases (DUBs) also play an important role in the regulation of Snail1 protein stability, including USP3, USP11, USP13, DUB3, USP18, USP26, USP27X, USP37, USP47, OTUB1, and PSMD14, that have been shown to facilitate deubiquitination and stabilization of nuclear Snail1 in promoting cell proliferation, migration, and invasion ."