IndraLab

Statements

OTUB1 deubiquitinates TRAF6. 6 / 7
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
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"OTUB1 also inhibits the polyubiquitination of TRAF6 and the subsequent activation of the ASK1 signaling pathway, playing a critical protective role in non-alcoholic fatty liver disease [22]."
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"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
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"OTUB1 and OTUB2, which are members of the OTUB deubiquitinase superfamily, may deubiquitinate TRAF3 and TRAF6, stop SeV-induced NF-κB and IRF3 activation, and aid in viral replication [41] ."
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