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OTUB1 deubiquitinates TRAF3. 9 / 10
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"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
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"Collectively, OTUB1 deubiquitinates TRAF3 to activate NLRP3 inflammasome, thereby leading to inflammation and remodeling of TGF-β1-induced cells, and further promoting the pathogenesis of asthma."
36976509
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
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"Instead, we discovered that phosphorylation-deficient FAT10 (FAT10 A) partially lost the capacity of binding to OTUB1 and to reduce the OTUB1-dependent deubiquitylation of TRAF3 (Fig 7)."
37940187
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"Furthermore, we found that OTUB1 and OTUB2 mediated virus triggered deubiquitination of TRAF3 and -6."
19996094
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
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"OTUB1 and OTUB2, which are members of the OTUB deubiquitinase superfamily, may deubiquitinate TRAF3 and TRAF6, stop SeV-induced NF-κB and IRF3 activation, and aid in viral replication [41] ."
37001379
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"Knockout of HSCARG attenuated the de-ubiquitination of TRAF3 by OTUB1, and knockdown of OTUB1 abolished the effect of HSCARG."
24763515