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OTUB1 deubiquitinates ESR1. 4 / 4
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"OTUB1 deubiquitinates ERalpha in vitro and in vivo and stabilizes ERalpha in the nucleus [XREF_BIBR]."

"OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.|We show that OTUB1 negatively regulates transcription mediated by ERalpha in transient reporter gene assays and transcription mediated by endogenous ERalpha in Ishikawa endometrial cancer cells."

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"OTUB1 deubiquitinates estrogen receptor α (ERα) and negatively regulates ERα mediated transcription ( Stanisic et al., 2009 )."

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